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首页> 美国卫生研究院文献>Frontiers in Pediatrics >Pathophysiology Management and Outcome of Persistent Pulmonary Hypertension of the Newborn: A Clinical Review
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Pathophysiology Management and Outcome of Persistent Pulmonary Hypertension of the Newborn: A Clinical Review

机译：新生儿持续性肺动脉高压的病理生理学治疗和结果：临床评价

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摘要

Persistent Pulmonary Hypertension of the Newborn (PPHN) results from the failure of relaxation of the pulmonary vasculature at birth, leading to shunting of non-oxygenated blood from the pulmonary to the systemic circulation. More often, full term and near-term infants are affected, however it is not uncommon to see PPHN in preterm infants who have respiratory distress syndrome. In some infants pulmonary vascular remodeling is present at birth, pointing toward the prenatal onset of the disease process. Regardless of the etiology, PPHN should be diagnosed and treated as soon as possible to avoid hypoxia related short term and long-term morbidities. The mainstay therapy is the treatment of the underlying condition along with several promising therapeutic modalities such as oxygen supplementation, mechanical ventilation, nitric oxide, phosphodiesterase inhibitors, prostaglandins analogs, endothelin receptor antagonists, and extracorporeal membrane oxygenation. The optimal approach to the management of PPHN remains controversial. After discharge from the NICU, infants with PPHN warrant long-term follow up since they are at risk for neurodevelopmental disabilities and chronic health conditions.
机译：新生儿持续性肺动脉高压（PPHN）是由于出生时肺血管舒张功能衰竭而导致的，导致无氧血液从肺部分流至全身循环。足月和近期婴儿经常受到影响，但是在患有呼吸窘迫综合征的早产婴儿中看到PPHN并不少见。在一些婴儿出生时就出现了肺血管重塑，这指向疾病过程的产前发作。不论病因如何，均应尽早诊断和治疗PPHN，以避免低氧引起的短期和长期发病。主流疗法是治疗潜在疾病以及几种有前景的治疗方式，例如补氧，机械通气，一氧化氮，磷酸二酯酶抑制剂，前列腺素类似物，内皮素受体拮抗剂和体外膜氧合。 PPHN管理的最佳方法仍存在争议。从新生儿重症监护病房（NICU）出院后，患有PPHN的婴儿应长期随访，因为他们有神经发育障碍和慢性健康状况的风险。

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