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首页> 美国卫生研究院文献>Frontiers in Surgery >Elevated Infant Mortality Rate among Dutch Oral Cleft Cases: A Retrospective Analysis from 1997 to 2011
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Elevated Infant Mortality Rate among Dutch Oral Cleft Cases: A Retrospective Analysis from 1997 to 2011

机译：荷兰口腔裂病例中婴儿死亡率的升高：1997年至2011年的回顾性分析

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>Objectives: First, to determine the infant mortality rate (IMR) for Dutch patients with isolated oral clefts (OC) as well as for patients with clefts seen in association with other malformations. Second, to conduct a similar analysis per cleft type: cleft lip with or without cleft palate (CP), CP (including Robin sequence). Third, to examine the underlying causes of death.>Material and Methods: A retrospective review of the charts of patients with OC born in the period 1997–2011 and treated in three regional cleft centers in the Netherlands.>Results: One thousand five hundred thirty patients with OC were born during the study period and treated in the cleft centers. The overall IMR for all clefts was 2.09%, significantly higher than the general Dutch IMR of 0.45%. In a subanalysis per cleft type, the IMRs were 1.22, 1.38, 2.45, and 3.62% for cleft lip, cleft lip with CP, CP, and Robin sequence, respectively. The mortality rates for isolated OC did not differ significantly from the general Dutch rate. Causes of death were congenital malformations of the heart in 40.6%, airway/lungs in 15.6%, nervous system in 15.6%, infectious disease in 12.5%, and other or unknown in 15.6%.>Conclusion: The elevated IMR observed in Dutch patients with OC is almost exclusively caused by associated congenital malformations. After diagnosis of an oral cleft an in-depth medical examination and a consult by the pediatrician and clinical geneticist is imperative to instigate the appropriate medical management.
机译：>目标：首先，确定孤立的口腔裂口（OC）的荷兰患者以及与其他畸形相关的裂口患者的婴儿死亡率（IMR）。其次，对每种c裂类型进行相似的分析：有或没有c裂（CP），CP（包括Robin序列）的唇裂。第三，检查潜在的死亡原因。>材料和方法：回顾性回顾了1997-2011年间出生于荷兰三个区域性裂隙中心的OC患者的病历。 strong>结果：在研究期间出生了1,530例OC患者，并在in裂中心进行了治疗。所有c裂的整体IMR为2.09％，明显高于荷兰普通IMR的0.45％。在每个c裂类型的亚分析中，c裂唇，具有CP，CP和Robin序列的left裂唇的IMR分别为1.22％，1.38％，2.45％和3.62％。孤立性OC的死亡率与荷兰的一般死亡率没有显着差异。死亡原因包括：先天性心脏畸形占40.6％，气道/肺占15.6％，神经系统占15.6％，传染病占12.5％，其他或未知占15.6％。>结论：在荷兰的OC患者中观察到的IMR升高几乎完全是由相关的先天性畸形引起的。诊断出口腔c裂后，必须进行深入的医学检查，并由儿科医生和临床遗传学家进行咨询，以鼓励采取适当的医学治疗方法。

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