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3D Bioprinting of Cartilage for Orthopedic Surgeons: Reading between the Lines

机译:骨科医生的软骨3D生物打印:在线条之间阅读

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摘要

Chondral and osteochondral lesions represent one of the most challenging and frustrating scenarios for the orthopedic surgeon and for the patient. The lack of therapeutic strategies capable to reconstitute the function and structure of hyaline cartilage and to halt the progression toward osteoarthritis has brought clinicians and scientists together, to investigate the potential role of tissue engineering as a viable alternative to current treatment modalities. In particular, the role of bioprinting is emerging as an innovative technology that allows for the creation of organized 3D tissue constructs via a “layer-by-layer” deposition process. This process also has the capability to combine cells and biomaterials in an ordered and predetermined way. Here, we review the recent advances in cartilage bioprinting and we identify the current challenges and the directions for future developments in cartilage regeneration.
机译:软骨和骨软骨病变代表整形外科医生和患者面临的最具挑战性和令人沮丧的情况之一。缺乏能够重建透明软骨功能和结构并阻止向骨关节炎发展的治疗策略,已经使临床医生和科学家聚集在一起,以研究组织工程作为当前治疗方式的可行替代方法的潜在作用。尤其是,生物打印的作用正在作为一种创新技术而出现,该技术可以通过“逐层”沉积过程创建有组织的3D组织构造。该过程还具有以有序和预定的方式结合细胞和生物材料的能力。在这里,我们回顾了软骨生物打印的最新进展,并确定了软骨再生的当前挑战和未来发展的方向。

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