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首页> 美国卫生研究院文献>Frontiers in Pharmacology >Nootropic and Neuroprotective Effects of Dichrocephala integrifolia on Scopolamine Mouse Model of Alzheimer’s Disease
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Nootropic and Neuroprotective Effects of Dichrocephala integrifolia on Scopolamine Mouse Model of Alzheimer’s Disease

机译：整枝线虫对东co碱小鼠阿尔茨海默氏病模型的促智和神经保护作用

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Alzheimer’s disease the most common form of dementia in the elderly is a neurodegenerative disease that affects 44 millions of people worldwide. The first treatments against Alzheimer’s disease are acetylcholinesterase inhibitors; however, these medications are associated with many side effects. Dichrocephala integrifolia is a traditional herb widely used by indigenous population of Cameroon to treat and prevent Alzheimer’s disease and for memory improvement. In this study, we evaluated the effect of the decoction prepared from leaves of D. integrifolia, on scopolamine-induced memory impairment in mice. Seven groups of six animals were used. The first two groups received distilled water for the distilled water and scopolamine groups. The four test groups received one of the four doses of the decoction of the plant (35, 87.5, 175 or 350 mg/kg p.o.) and the positive control group received tacrine (10 mg/kg), a cholinesterase inhibitor used in the treatment of Alzheimer’s disease, during 10 consecutive days. Scopolamine (1 mg/kg), a cholinergic receptor blocker, administered 30 min after treatments, was used to induce memory impairment to all groups except the distilled water group on day 10 of drug treatment. The behavioral paradigms used to evaluate the effects of the treatment were the elevated plus maze for learning and memory, Y maze for spatial short-term memory, the novel object recognition for recognition memory and Morris water maze for the evaluation of spatial long-term memory. After behavioral tests, animals were sacrificed and brains of a subset were used for the assessment of some biomarkers of oxidative stress (malondialdehyde and reduced glutathione levels) and for the evaluation of the acetylcholinesterase activity. From the remaining subset brains, histopathological analysis was performed. The results of this study showed that, D. integrifolia at the doses of 87.5 and 350 mg/kg significantly (p < 0.01) improved spatial short-term and long-term memory, by increasing the percentage of spontaneous alternation in the Y maze and reducing the escape latency in the Morris water maze. Furthermore, the results of histopathological evaluation showed that D. integrifolia attenuated the neuronal death in the hippocampus induced by scopolamine. The main finding of this work is that D. integrifolia improves learning capacities and counteracts the memory impairment induced by scopolamine. Thus, D. integrifolia can be a promising plant resource for the management of Alzheimer’s disease and memory loss.
机译：老年痴呆症最常见的形式是老年痴呆症，是一种神经退行性疾病，影响全球4400万人。阿尔茨海默氏病的首批治疗方法是乙酰胆碱酯酶抑制剂。然而，这些药物与许多副作用有关。 Dichrocephala integrifolia是喀麦隆土著居民广泛使用的传统草药，用于治疗和预防阿尔茨海默氏病和改善记忆力。在这项研究中，我们评估了由D. integrifolia叶片制备的煎剂对东pol碱诱导的小鼠记忆力损伤的作用。使用七组六只动物。前两组分别接受蒸馏水和东pol碱组。四个测试组接受四种植物汤剂之一（35、87.5、175或350 mg / kg po），阳性对照组接受他克林（10 mg / kg），一种用于治疗的胆碱酯酶抑制剂连续10天服用阿尔茨海默氏病。在治疗后第30天，给予胆碱能受体阻滞剂东co碱（1 mg / kg），以诱导除蒸馏水组外的所有组的记忆障碍。用于评估治疗效果的行为范式是用于学习和记忆的高架加迷宫，用于空间短期记忆的Y迷宫，用于识别记忆的新型物体识别以及用于评估空间长期记忆的莫里斯水迷宫。进行行为测试后，处死动物，并将其子集的大脑用于评估某些氧化应激的生物标记（丙二醛和降低的谷胱甘肽水平）和评估乙酰胆碱酯酶活性。从其余的子集大脑中进行了组织病理学分析。这项研究的结果表明，D。integrifolia剂量为87.5和350 mg / kg（p <0.01），可通过增加Y迷宫中自发交替的百分比和显着改善空间短期和长期记忆。减少莫里斯水迷宫的逃逸潜伏期。此外，组织病理学评估的结果表明，整枝杜鹃可减轻东pol碱所致海马神经元的死亡。这项工作的主要发现是整枝杜鹃提高了学习能力并抵消了东pol碱引起的记忆障碍。因此，D。integrifolia可以成为治疗阿尔茨海默氏病和记忆力丧失的有前途的植物资源。

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