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The Role of Dopamine in Schizophrenia from a Neurobiological and Evolutionary Perspective: Old Fashioned but Still in Vogue

机译:从神经生物学和进化的角度看多巴胺在精神分裂症中的作用:老式但仍在流行

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摘要

Dopamine is an inhibitory neurotransmitter involved in the pathology of schizophrenia. The revised dopamine hypothesis states that dopamine abnormalities in the mesolimbic and prefrontal brain regions exist in schizophrenia. However, recent research has indicated that glutamate, GABA, acetylcholine, and serotonin alterations are also involved in the pathology of schizophrenia. This review provides an in-depth analysis of dopamine in animal models of schizophrenia and also focuses on dopamine and cognition. Furthermore, this review provides not only an overview of dopamine receptors and the antipsychotic effects of treatments targeting them but also an outline of dopamine and its interaction with other neurochemical models of schizophrenia. The roles of dopamine in the evolution of the human brain and human mental abilities, which are affected in schizophrenia patients, are also discussed.
机译:多巴胺是一种与精神分裂症病理有关的抑制性神经递质。修正的多巴胺假说指出,精神分裂症存在中边缘和前额脑区域的多巴胺异常。但是,最近的研究表明,谷氨酸,GABA,乙酰胆碱和5-羟色胺的改变也与精神分裂症的病理有关。这篇评论提供了精神分裂症动物模型中的多巴胺的深入分析,并且还着重于多巴胺和认知。此外,本综述不仅概述了多巴胺受体及其靶向治疗的抗精神病作用,还概述了多巴胺及其与精神分裂症其他神经化学模型的相互作用。还讨论了多巴胺在精神分裂症患者中受到影响的人类大脑和人类智力发展中的作用。

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