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首页> 美国卫生研究院文献>Frontiers in Molecular Biosciences >Ser or Leu: structural snapshots of mistranslation in Candida albicans
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Ser or Leu: structural snapshots of mistranslation in Candida albicans

机译：Ser或Leu：白色假丝酵母误译的结构快照

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摘要

Candida albicans is a polymorphic opportunistic fungal pathogen normally residing as commensal on mucosal surfaces, skin and gastrointestinal and genitourinary tracts. However, in immunocompromised patients C. albicans can cause superficial mucosal infections or life-threatening disseminated candidemia. A change in physiological conditions triggers a cascade of molecular events leading to morphogenetic alterations and increased resistance to damage induced by host defenses. The complex biology of this human pathogen is reflected in its morphological plasticity and reinforced by the ability to ambiguously translate the universal leucine CUG codon predominantly as serine, but also as leucine. Mistranslation affects more than half of C. albicans proteome and it is widespread across many biological processes. A previous analysis of CTG-codon containing gene products in C. albicans suggested that codon ambiguity subtly shapes protein function and might have a pivotal role in signaling cascades associated with morphological changes and pathogenesis. In this review we further explore this hypothesis by highlighting the role of ambiguous decoding in macromolecular recognition of key effector proteins associated with the regulation of signal transduction cascades and the cell cycle, which are critical processes for C. albicans morphogenic plasticity under a variety of environmental conditions.
机译：白色念珠菌是多态性真菌病原体，通常作为粘膜表面，皮肤，胃肠道和泌尿生殖道的共生体。然而，在免疫功能低下的患者中，白色念珠菌可引起浅表粘膜感染或危及生命的传播性念珠菌血症。生理条件的变化会触发一系列分子事件，从而导致形态发生改变并增强对宿主防御系统诱导的伤害的抵抗力。这种人类病原体的复杂生物学表现为其形态可塑性，并通过将通用亮氨酸CUG密码子主要翻译成丝氨酸，也翻译成亮氨酸的能力而得到加强。错误翻译影响超过一半的白色念珠菌蛋白质组，并且在许多生物过程中普遍存在。先前对白色念珠菌中含有CTG密码子的基因产物的分析表明，密码子的含糊性巧妙地影响了蛋白质的功能，并可能在与形态变化和发病机制相关的级联信号转导中起关键作用。在这篇综述中，我们通过突显模棱两可的解码在大分子识别与信号转导级联和细胞周期调控相关的关键效应蛋白的大分子识别中的作用，进一步探讨了这一假设，这是在多种环境下白念珠菌形态发生可塑性的关键过程。条件。

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