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首页> 美国卫生研究院文献>Frontiers in Molecular Biosciences >N-glycomic Complexity in Anatomical Simplicity: Caenorhabditis elegans as a Non-model Nematode?
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N-glycomic Complexity in Anatomical Simplicity: Caenorhabditis elegans as a Non-model Nematode?

机译：N糖基复杂性在解剖上的简单性：秀丽隐杆线虫是非模型线虫吗？

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摘要

Caenorhabditis elegans is a genetically well-studied model nematode or “worm”; however, its N-glycomic complexity is actually baffling and still not completely unraveled. Some features of its N-glycans are, to date, unique and include bisecting galactose and up to five fucose residues associated with the asparagine-linked Man2−3GlcNAc2 core; the substitutions include galactosylation of fucose, fucosylation of galactose and methylation of mannose or fucose residues as well as phosphorylcholine on antennal (non-reducing) N-acetylglucosamine. Only some of these modifications are shared with various other nematodes, while others have yet to be detected in any other species. Thus, C. elegans can be used as a model for some aspects of N-glycan function, but its glycome is far from identical to those of other organisms and is actually far from simple. Possibly the challenges of its native environment, which differ from those of parasitic or necromenic species, led to an anatomically simple worm possessing a complex glycome.
机译：秀丽隐杆线虫是一种经过基因研究的线虫或“线虫”模型。然而，其N糖组学的复杂性实际上令人困惑，仍未完全阐明。迄今为止，其N-聚糖的某些特征是独特的，包括二等分的半乳糖和最多5个与天冬酰胺连接的Man2-3GlcNAc2核心相关的岩藻糖残基。取代包括岩藻糖的半乳糖基化，半乳糖的岩藻糖基化和甘露糖或岩藻糖残基的甲基化，以及触角（非还原性）N-乙酰基葡糖胺上的磷酸胆碱。这些修饰中只有一部分与其他各种线虫共有，而其他任何种类中尚未发现其他修饰。因此，秀丽隐杆线虫可以用作N-聚糖功能某些方面的模型，但是它的糖原与其他生物的糖原远非相同，实际上远非简单。可能其本土环境所面临的挑战与寄生或死灵物种不同，这导致解剖学上简单的蠕虫具有复杂的糖组。

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