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首页> 美国卫生研究院文献>Frontiers in Neuroanatomy >Cannabinoid melanocortin and opioid receptor expression on DRD1 and DRD2 subpopulations in rat striatum
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Cannabinoid melanocortin and opioid receptor expression on DRD1 and DRD2 subpopulations in rat striatum

机译：大鼠纹状体DRD1和DRD2亚群上的大麻素黑皮质素和阿片受体表达

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摘要

The striatum harbors two neuronal populations that enable action selection. One population represents the striatonigral pathway, expresses the dopamine receptor D1 (DRD1) and promotes the execution of motor programs, while the other population represents the striatopallidal pathway, expresses the dopamine receptor D2 (DRD2) and suppresses voluntary activity. The two populations integrate distinct sensorimotor, cognitive, and emotional information streams and their combined activity enables the selection of adaptive behaviors. Characterization of these populations is critical to the understanding of their role in action selection, because it aids the identification of the molecular mechanisms that separate them. To that end, we used fluorescent in situ hybridization to quantify the percentage of striatal cells that (co)express dopaminergic receptors and receptors of the cannabinoid, melanocortin or opioid neurotransmitters systems. Our main findings are that the cannabinoid 1 receptor is equally expressed on both populations with a gradient from dorsal to ventral striatum, that the opioid receptors have a preference for expression with either the DRD1 or DRD2 and that the melanocortin 4 receptor (MC4R) is predominantly expressed in ventral parts of the striatum. In addition, we find that the level of MC4R expression determines its localization to either the DRD1 or the DRD2 population. Thereby, we provide insight into the sensitivity of the two dopaminoceptive populations to these neurotransmitters and progress the understanding of the mechanisms that enable action selection.
机译：纹状体包含两个神经元种群，可以选择行动。一个种群代表纹状体神经通路，表达多巴胺受体D1（DRD1）并促进运动程序的执行，而另一种群代表纹状体神经通路，表达多巴胺受体D2（DRD2）并抑制自愿活动。这两个人群整合了不同的感觉运动，认知和情感信息流，它们的结合活动使得能够选择适应性行为。这些种群的表征对于理解它们在行动选择中的作用至关重要，因为它有助于识别将它们分开的分子机制。为此，我们使用了荧光原位杂交技术来定量（共）表达多巴胺能受体和大麻素，黑皮质素或阿片类神经递质系统受体的纹状体细胞的百分比。我们的主要发现是，大麻素1受体在两个种群中均以从背侧到腹侧纹状体的梯度均等表达，阿片受体优先于DRD1或DRD2表达，而黑皮质素4受体（MC4R）主要表达在纹状体腹侧部分表达。此外，我们发现MC4R表达水平决定了它对DRD1或DRD2群体的定位。因此，我们提供了两个多巴胺受体群体对这些神经递质的敏感性的见解，并增进了对使动作选择的机制的理解。

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