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Lights Camera and Action: Vertebrate Skin Sets the Stage for Immune Cell Interaction with Arthropod-Vectored Pathogens

机译:灯光摄像头和动作:脊椎动物的皮肤为节肢动物病原体与免疫细胞的相互作用奠定了基础

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摘要

Despite increasing studies targeted at host-pathogen interactions, vector-borne diseases remain one of the largest economic health burdens worldwide. Such diseases are vectored by hematophagous arthropods that deposit pathogens into the vertebrate host’s skin during a blood meal. These pathogens spend a substantial amount of time in the skin that allows for interaction with cutaneous immune cells, suggesting a window of opportunity for development of vaccine strategies. In particular, the recent availability of intravital imaging approaches has provided further insights into immune cell behavior in living tissues. Here, we discuss how such intravital imaging studies have contributed to our knowledge of cutaneous immune cell behavior and specifically, toward pathogen and tissue trauma from the arthropod bite. We also suggest future imaging approaches that may aid in better understanding of the complex interplay between arthropod-vectored pathogens and cutaneous immunity that could lead to improved therapeutic strategies.
机译:尽管针对宿主-病原体相互作用的研究越来越多,但媒介传播疾病仍然是世界范围内最大的经济健康负担之一。这类疾病是由食血节肢动物传播的,食血节肢动物在吃血时将病原体沉积到脊椎动物宿主的皮肤中。这些病原体在皮肤上花费了大量时间,可以与皮肤免疫细胞相互作用,这为开发疫苗策略提供了机会之窗。特别地,最近的活体内成像方法的可用性提供了对活组织中免疫细胞行为的进一步了解。在这里,我们讨论了这种活体内成像研究如何促进我们对皮肤免疫细胞行为的了解,特别是对节肢动物叮咬致病原体和组织的伤害。我们还建议未来的影像学方法可能有助于更好地了解节肢动物媒介病原体与皮肤免疫力之间的复杂相互作用,从而可能改善治疗策略。

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