Cell-Mediated Immunity in Elite Controllers Naturally Controlling HIV Viral Load

机译：自然控制HIV病毒载量的精英控制者中的细胞介导的免疫

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The natural course of human immunodeficiency virus (HIV) infection is characterized by high viral load, depletion of immune cells, and immunodeficiency, ultimately leading to acquired immunodeficiency syndrome phase and the occurrence of opportunistic infections and diseases. Since the discovery of HIV in the early 1980s a naturally selected population of infected individuals has been emerged in the last years, characterized by being infected for many years, with viremia constantly below detectable level and poor depletion of immune cells. These individuals are classified as “elite controllers (EC) or suppressors” and do not develop disease in the absence of anti-retroviral therapy. Unveiling host factors and immune responses responsible for the elite status will likely provide clues for the design of therapeutic vaccines and functional cures. Scope of this review was to examine and discuss differences of the cell-mediated immune responses between HIV+ individuals with disease progression and EC.

机译：人类免疫缺陷病毒（HIV）感染的自然过程的特点是病毒载量高，免疫细胞耗竭和免疫缺陷，最终导致获得性免疫缺陷综合症阶段以及机会性感染和疾病的发生。自从1980年代初期发现HIV以来，最近几年出现了自然选择的感染个体群体，其特征是感染了许多年，病毒血症不断降低到可检测水平以下，免疫细胞耗竭不佳。这些人被归类为“精英控制者（EC）或抑制者”，在没有抗逆转录病毒疗法的情况下不会发展疾病。揭示导致精英地位的宿主因素和免疫反应可能会为治疗性疫苗和功能性治疗的设计提供线索。这篇综述的范围是检查和讨论具有疾病进展和EC的HIV +个体之间细胞介导的免疫反应的差异。

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期刊名称 Frontiers in Immunology
作者
Luca Genovese; Manuela Nebuloni; Massimo Alfano;
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年(卷),期 2013(4),-1
年度 2013
页码 86
总页数 12
原文格式 PDF
正文语种
中图分类免疫学;
关键词
HIV elite controllers long-term non progressors AIDS innate immunity cytokines/chemokines;

机译：HIV;精英控制者;长期无进展者;艾滋病;先天免疫;细胞因子/趋化因子;

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专利

1. HIV long-term non-progressors elite controllers: an interplay between host, immune and viral factors [J] . Lopez-Galindez Cecilio Future Virology . 2019,第4期

机译：艾滋病毒长期非进展精英控制器：宿主，免疫和病毒因素之间的相互作用
2. Increased frequency of systemic pro-inflammatory Vδ1 + γδ T cells in HIV elite controllers correlates with gut viral load [J] . Gregory S. Olson, Sarah W. Moore, James M. Richter, Scientific reports. . 2018,第1期

机译：HIV精英控制者中全身促炎性Vδ1+γδT细胞频率增加与肠道病毒载量相关
3. Potent Cell-Intrinsic Immune Responses in Dendritic Cells Facilitate HIV-1-Specific T Cell Immunity in HIV-1 Elite Controllers [J] . Bruce D. Walker, Dina Pimenova, Enrique Martin-Gayo, PLoS Pathogens . 2015,第6期

机译：树突状细胞中强大的细胞内在免疫反应可促进HIV-1精英控制者中HIV-1特异的T细胞免疫。
4. Stochastic cellular automata for HIV infection with effects of cell-mediated immunity [C] . M. Precharattana, W. Triampo International Conference on Scientific Computing . 2012

机译：用于HIV感染的随机细胞自动机，具有细胞介导的免疫影响
5. Persistence of HIV-1 despite highly active antiretroviral therapy (HAART) and immune responses: Evidence for a novel viral reservoir in patients on HAART and characterization of HIV-1 virus and immune responses in elite suppressors. [D] . Bailey, Justin R. 2007

机译：尽管有高活性的抗逆转录病毒疗法（HAART）和免疫应答，但HIV-1仍持续存在：有证据表明在HAART患者中出现了新型病毒库，并且有关于HIV-1病毒和精英抑制者免疫应答的特征。
6. A Correlate of HIV-1 Control Consisting of Both Innate and Adaptive Immune Parameters Best Predicts Viral Load by Multivariable Analysis in HIV-1 Infected Viremic Controllers and Chronically-Infected Non-Controllers [O] . Costin Tomescu, Qin Liu, Brian N. Ross, -1

机译：通过自然变量和适应性免疫参数组成的HIV-1对照的相关性可以通过HIV-1感染的病毒控制者和慢性感染的非控制者的多变量分析最好地预测病毒载量
7. Cell-mediated Immunity in Elite Controllers Naturally Controlling HIV Viral Load [O] . Luca eGenovese, Manuela eNebuloni, Massimo eAlfano 2013

机译：自然控制HIV病毒载量的精细控制器中的细胞介导的免疫

Cell-Mediated Immunity in Elite Controllers Naturally Controlling HIV Viral Load

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