首页> 美国卫生研究院文献>Frontiers in Immunology >Altered Tryptophan Metabolism as a Paradigm for Good and Bad Aspects of Immune Privilege in Chronic Inflammatory Diseases

【2h】

Altered Tryptophan Metabolism as a Paradigm for Good and Bad Aspects of Immune Privilege in Chronic Inflammatory Diseases

机译：色氨酸代谢改变是慢性炎性疾病免疫特权的好坏方面的范例

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

The term “immune privilege” was coined to describe weak immunogenicity (hypo-immunity) that manifests in some transplant settings. We extended this concept to encompass hypo-immunity that manifests at local sites of inflammation relevant to clinical diseases. Here, we focus on emerging evidence that enhanced tryptophan catabolism is a key metabolic process that promotes and sustains induced immune privilege, and discuss the implications for exploiting this knowledge to improve treatments for hypo-immune and hyper-immune syndromes using strategies to manipulate tryptophan metabolism.

机译：创造“免疫特权”一词是为了描述在某些移植环境中表现出的弱免疫原性（低免疫性）。我们将这一概念扩展到涵盖在与临床疾病相关的炎症局部部位出现的免疫低下。在这里，我们集中于新兴的证据，即色氨酸分解代谢是促进和维持诱导的免疫特权的关键代谢过程，并讨论了利用该知识来利用色氨酸代谢策略改善对低免疫和高免疫综合征的治疗方法的意义。。

著录项

期刊名称 Frontiers in Immunology
作者
Lingqian Li; Lei Huang; Henrique P. Lemos; Mario Mautino; Andrew L. Mellor;
展开▼
作者单位

展开▼
年(卷),期 2012(3),-1
年度 2012
页码 109
总页数 14
原文格式 PDF
正文语种
中图分类免疫学;
关键词
IDO inflammation immunity regulation tolerance;

机译：IDO;炎症;免疫力;调节;耐受;

相似文献

外文文献
中文文献
专利

1. Altered Tryptophan Levels in Patients With Inflammatory Bowel Disease Owing to Colonic Leakage, Metabolism, or Malabsorption? Reply [J] . Schreiber Stefan, Nikolaus Susanna, Waetzig Georg H., Gastroenterology . 2018,第8期

机译：由于结肠渗漏，新陈代谢或吸收吸收，改变了炎症性肠病患者的色氨酸水平？回复
2. Altered Tryptophan Levels in Patients With Inflammatory Bowel Disease Owing to Colonic Leakage, Metabolism, or Malabsorption? [J] . Bosch Sofie, de Meij Tim G. J., De Boer Nanne K. H. Gastroenterology . 2018,第6期

机译：由于结肠渗漏，新陈代谢或吸收吸收，改变了炎症性肠病患者的色氨酸水平？
3. Tryptophan Metabolism in Patients With Chronic Kidney Disease Secondary to Type 2 Diabetes: Relationship to Inflammatory Markers: [J] . Subrata Debnath, Chakradhar Velagapudi, Laney Redus, International Journal of Tryptophan Research . 2017,第1期

机译：继发于2型糖尿病的慢性肾脏病患者的色氨酸代谢：与炎症标志物的关系：
4. Clinical aspects of indoleamine 2,3-dioxygenase(IDO)-initiated tryptophan metabolism: IDO is atarget of drug discovery for various diseases [C] . O. Takikaw International Study Group for Tryptophan Research . 2007

机译：吲哚胺2,3-二恶英酶（IDO） - intinited色氨酸代谢的临床方面：IDO是各种疾病的药物发现的悖论
5. Symptoms, functional status, and altered immunity in survivors of allogeneic hematopoietic stem cell transplantation with chronic graft-versus-host disease (cGVHD). [D] . Mitchell, Sandra A. 2008

机译：慢性移植物抗宿主病（cGVHD）的同种异体造血干细胞移植的幸存者的症状，功能状态和免疫力改变。
6. Tryptophan Metabolism in Patients With Chronic Kidney Disease Secondary to Type 2 Diabetes: Relationship to Inflammatory Markers [O] . Subrata Debnath, Chakradhar Velagapudi, Laney Redus, 2017

机译：继发于2型糖尿病的慢性肾脏病患者的色氨酸代谢：与炎症标志物的关系
7. Altered Tryptophan Metabolism as a Paradigm for Good and Bad Aspects of Immune Privilege in Chronic Inflammatory Diseases [O] . Li, Lingqian, Huang, Lei, Lemos, Henrique P., 2012

机译：色氨酸代谢改变是慢性炎性疾病免疫特权的好坏方面的范例

Altered Tryptophan Metabolism as a Paradigm for Good and Bad Aspects of Immune Privilege in Chronic Inflammatory Diseases

摘要

著录项

相似文献

相关主题

期刊订阅