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首页> 美国卫生研究院文献>Frontiers in Neuroengineering >A Low-Cost Multielectrode System for Data Acquisition Enabling Real-Time Closed-Loop Processing with Rapid Recovery from Stimulation Artifacts
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A Low-Cost Multielectrode System for Data Acquisition Enabling Real-Time Closed-Loop Processing with Rapid Recovery from Stimulation Artifacts

机译：一种低成本的多电极系统用于数据采集可从刺激伪像中快速恢复实时闭环处理

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Commercially available data acquisition systems for multielectrode recording from freely moving animals are expensive, often rely on proprietary software, and do not provide detailed, modifiable circuit schematics. When used in conjunction with electrical stimulation, they are prone to prolonged, saturating stimulation artifacts that prevent the recording of short-latency evoked responses. Yet electrical stimulation is integral to many experimental designs, and critical for emerging brain-computer interfacing and neuroprosthetic applications. To address these issues, we developed an easy-to-use, modifiable, and inexpensive system for multielectrode neural recording and stimulation. Setup costs are less than US$10,000 for 64 channels, an order of magnitude lower than comparable commercial systems. Unlike commercial equipment, the system recovers rapidly from stimulation and allows short-latency action potentials (<1 ms post-stimulus) to be detected, facilitating closed-loop applications and exposing neural activity that would otherwise remain hidden. To illustrate this capability, evoked activity from microstimulation of the rodent hippocampus is presented. System noise levels are similar to existing platforms, and extracellular action potentials and local field potentials can be recorded simultaneously. The system is modular, in banks of 16 channels, and flexible in usage: while primarily designed for in vivo use, it can be combined with commercial preamplifiers to record from in vitro multielectrode arrays. The system's open-source control software, NeuroRighter, is implemented in C#, with an easy-to-use graphical interface. As C# functions in a managed code environment, which may impact performance, analysis was conducted to ensure comparable speed to C++ for this application. Hardware schematics, layout files, and software are freely available. Since maintaining wired headstage connections with freely moving animals is difficult, we describe a new method of electrode-headstage coupling using neodymium magnets.
机译：用于从自由移动的动物进行多电极记录的市售数据采集系统价格昂贵，通常依赖于专有软件，并且不提供详细的，可修改的电路原理图。当与电刺激结合使用时，它们容易出现长时间的饱和刺激伪影，从而阻止记录短时诱发反应。然而，电刺激是许多实验设计不可或缺的，对于新兴的脑机接口和神经修复应用至关重要。为了解决这些问题，我们开发了一种易于使用，可修改且便宜的多电极神经记录和刺激系统。 64个通道的安装成本不到10,000美元，比同类商用系统低一个数量级。与商用设备不同，该系统可从刺激中快速恢复，并允许检测到短时潜伏动作电位（刺激后<1µms），从而有利于闭环应用并暴露出原本会隐藏的神经活动。为了说明这种能力，提出了啮齿动物海马微刺激引起的活动。系统噪声水平与现有平台相似，并且可以同时记录细胞外动作电位和局部场电位。该系统是模块化的，有16个通道，并且使用灵活：虽然主要设计用于体内使用，但可以与商用前置放大器结合使用，以从体外多电极阵列进行记录。该系统的开源控制软件NeuroRighter用C＃实现，具有易于使用的图形界面。由于C＃在托管代码环境中运行（这可能会影响性能），因此进行了分析以确保该应用程序的速度可与C ++相提并论。硬件原理图，布局文件和软件可免费获得。由于很难与自由活动的动物保持有线的头级连接，因此，我们描述了一种使用钕磁体的电极-头级耦合的新方法。

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