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首页> 美国卫生研究院文献>Frontiers in Neuroengineering >Characterizing relationships of DTI fMRI and motor recovery in stroke rehabilitation utilizing brain-computer interface technology
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Characterizing relationships of DTI fMRI and motor recovery in stroke rehabilitation utilizing brain-computer interface technology

机译：利用脑机接口技术表征中风康复中DTIfMRI和运动恢复的关系

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The relationship of the structural integrity of white matter tracts and cortical activity to motor functional outcomes in stroke patients is of particular interest in understanding mechanisms of brain structural and functional changes while recovering from stroke. This study aims to probe these underlying mechanisms using diffusion tensor imaging (DTI) and fMRI measures. We examined the structural integrity of the posterior limb of the internal capsule (PLIC) using DTI and corticomotor activity using motor-task fMRI in stroke patients who completed up to 15 sessions of rehabilitation therapy using Brain-Computer Interface (BCI) technology. We hypothesized that (1) the structural integrity of PLIC and corticomotor activity are affected by stroke; (2) changes in structural integrity and corticomotor activity following BCI intervention are related to motor recovery; (3) there is a potential relationship between structural integrity and corticomotor activity. We found that (1) the ipsilesional PLIC showed significantly decreased fractional anisotropy (FA) values when compared to the contralesional PLIC; (2) lower ipsilesional PLIC-FA values were significantly associated with worse motor outcomes (i.e., ipsilesional PLIC-FA and motor outcomes were positively correlated.); (3) lower ipsilesional PLIC-FA values were significantly associated with greater ipsilesional corticomotor activity during impaired-finger-tapping-task fMRI (i.e., ipsilesional PLIC-FA and ipsilesional corticomotor activity were negatively correlated), with an overall bilateral pattern of corticomotor activity observed; and (4) baseline FA values predicted motor recovery assessed after BCI intervention. These findings suggest that (1) greater vs. lesser microstructural integrity of the ipsilesional PLIC may contribute toward better vs. poor motor recovery respectively in the stroke-affected limb and demand lesser vs. greater cortical activity respectively from the ipsilesional motor cortex; and that (2) PLIC-FA is a promising biomarker in tracking and predicting motor functional recovery in stroke patients receiving BCI intervention.
机译：脑卒中患者的白质束结构完整性和皮质活动与运动功能结局之间的关系对于理解脑卒中恢复时大脑结构和功能变化的机制尤为重要。这项研究旨在探索使用扩散张量成像（DTI）和功能磁共振成像的措施这些潜在的机制。我们使用脑机接口（BCI）技术完成了多达15次康复治疗的卒中患者，使用DTI检查了内部胶囊（PLIC）后肢的结构完整性，并使用运动任务功能磁共振成像检查了其皮质运动活动。我们假设（1）PLIC的结构完整性和皮质运动活性受中风影响； （2）BCI干预后结构完整性和皮质运动活动的变化与运动恢复有关； （3）在结构完整性和皮质运动活性之间存在潜在的关系。我们发现（1）与对侧PLIC相比，同侧PLIC的分数各向异性（FA）值显着降低； （2）较低的同侧PLIC-FA值与较差的运动结果显着相关（即同侧PLIC-FA与运动结果呈正相关）; （3）在手指轻击任务功能性磁共振成像受损期间，较低的PLIC-FA值与较高的皮层皮质运动活动显着相关（即，同侧PLIC-FA与皮层皮质运动活动呈负相关），与皮层活动的总体双侧模式有关观测到的; （4）BCI干预后评估的基线FA值预测了运动恢复。这些发现表明：（1）患病的PLIC的微结构完整性的好坏可能分别导致卒中患肢运动恢复的好坏，而对运动学皮层的皮质活动的需求则要小得多。 （2）PLIC-FA是追踪和预测接受BCI干预的中风患者运动功能恢复的有前途的生物标志物。

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