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首页> 美国卫生研究院文献>Frontiers in Neural Circuits >Development of glycinergic innervation to the murine LSO and SPN in the presence and absence of the MNTB
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Development of glycinergic innervation to the murine LSO and SPN in the presence and absence of the MNTB

机译：在存在和不存在MNTB的情况下对鼠LSO和SPN进行甘氨酸能神经支配的发展

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Neurons in the superior olivary complex (SOC) integrate excitatory and inhibitory inputs to localize sounds in space. The majority of these inhibitory inputs have been thought to arise within the SOC from the medial nucleus of the trapezoid body (MNTB). However, recent work demonstrates that glycinergic innervation of the SOC persists in Egr2; En1CKO mice that lack MNTB neurons, suggesting that there are other sources of this innervation (). To study the development of MNTB- and non-MNTB-derived glycinergic SOC innervation, we compared immunostaining patterns of glycine transporter 2 (GlyT2) at several postnatal ages in control and Egr2; En1CKO mice. GlyT2 immunostaining was present at birth (P0) in controls and reached adult levels by P7 in the superior paraolivary nucleus (SPN) and by P12 in the lateral superior olive (LSO). In Egr2; En1CKO mice, glycinergic innervation of the LSO developed at a similar rate but was delayed by one week in the SPN. Conversely, consistent reductions in the number of GlyT2+ boutons located on LSO somata were seen at all ages in Egr2; En1CKO mice, while these numbers reached control levels in the SPN by adulthood. Dendritic localization of GlyT2+ boutons was unaltered in both the LSO and SPN of adult Egr2; En1CKO mice. On the postsynaptic side, adult Egr2; En1CKO mice had reduced glycine receptor α1 (GlyRα1) expression in the LSO but normal levels in the SPN. GlyRα2 was not expressed by LSO or SPN neurons in either genotype. These findings contribute important information for understanding the development of MNTB- and non-MNTB-derived glycinergic pathways to the mouse SOC.
机译：上橄榄复合体（SOC）中的神经元整合了兴奋性和抑制性输入，以定位空间中的声音。这些抑制性输入中的大多数被认为是在SOC内从梯形体（MNTB）的中间核产生的。但是，最近的研究表明，SOC的甘氨酸能神经支配在Egr2中持续存在。缺少MNTB神经元的En1 CKO 小鼠，提示这种神经支配还有其他来源（）。为了研究MNTB和非MNTB衍生的甘氨酸能SOC的神经支配的发展，我们比较了几个出生后对照和Egr2中甘氨酸转运蛋白2（GlyT2）的免疫染色模式。 En1 CKO 小鼠。 GlyT2免疫染色在出生时（P0）存在于对照组中，并在上橄榄旁核（SPN）中通过P7和在外侧橄榄上侧（LSO）中通过P12达到成人水平。在Egr2中； En1 CKO 小鼠，LSO的甘氨酸能神经支配以相似的速度发展，但在SPN中延迟了一周。相反，在Egr2的所有年龄段中，位于LSO躯体上的GlyT2 + 钮扣的数量均不断减少； En1 CKO 小鼠，但成年后这些数量已达到SPN中的对照水平。在成年Egr2的LSO和SPN中，GlyT2 + boutons的树突状定位均未改变。 En1 CKO 小鼠。在突触后，成年Egr2； En1 CKO 小鼠的LSO中的甘氨酸受体α1（GlyRα1）表达降低，但SPN中的水平正常。两种基因型的LSO或SPN神经元均未表达GlyRα2。这些发现为了解小鼠SOC的MNTB和非MNTB衍生的甘氨酸能途径的发展提供了重要信息。

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