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首页> 美国卫生研究院文献>Frontiers in Microbiology >Proteinaceous determinants of surface colonization in bacteria: bacterial adhesion and biofilm formation from a protein secretion perspective
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Proteinaceous determinants of surface colonization in bacteria: bacterial adhesion and biofilm formation from a protein secretion perspective

机译：细菌在细菌表面定殖的决定因素：从蛋白质分泌的角度看细菌粘附和生物膜形成

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Bacterial colonization of biotic or abiotic surfaces results from two quite distinct physiological processes, namely bacterial adhesion and biofilm formation. Broadly speaking, a biofilm is defined as the sessile development of microbial cells. Biofilm formation arises following bacterial adhesion but not all single bacterial cells adhering reversibly or irreversibly engage inexorably into a sessile mode of growth. Among molecular determinants promoting bacterial colonization, surface proteins are the most functionally diverse active components. To be present on the bacterial cell surface, though, a protein must be secreted in the first place. Considering the close association of secreted proteins with their cognate secretion systems, the secretome (which refers both to the secretion systems and their protein substrates) is a key concept to apprehend the protein secretion and related physiological functions. The protein secretion systems are here considered in light of the differences in the cell-envelope architecture between diderm-LPS (archetypal Gram-negative), monoderm (archetypal Gram-positive) and diderm-mycolate (archetypal acid-fast) bacteria. Besides, their cognate secreted proteins engaged in the bacterial colonization process are regarded from single protein to supramolecular protein structure as well as the non-classical protein secretion. This state-of-the-art on the complement of the secretome (the secretion systems and their cognate effectors) involved in the surface colonization process in diderm-LPS and monoderm bacteria paves the way for future research directions in the field.
机译：生物或非生物表面的细菌定植来自两个截然不同的生理过程，即细菌粘附和生物膜形成。从广义上讲，生物膜被定义为微生物细胞的无柄发育。生物膜的形成是在细菌粘附后发生的，但并非所有可逆或不可逆地粘附的单个细菌细胞都不可避免地进入无柄生长模式。在促进细菌定殖的分子决定因素中，表面蛋白是功能最丰富的活性成分。但是，要想存在于细菌细胞表面，必须首先分泌一种蛋白质。考虑到分泌的蛋白质与其同源分泌系统的紧密联系，分泌组（既指分泌系统又涉及其蛋白质底物）是理解蛋白质分泌和相关生理功能的关键概念。根据diderm-LPS（原型革兰氏阴性），monoderm（原型革兰氏阳性）和diderm-霉菌酸酯（原型耐酸）细菌之间的细胞包膜结构差异，来考虑蛋白质分泌系统。此外，它们参与细菌定殖过程的同源分泌蛋白被认为是从单一蛋白到超分子蛋白结构，以及非经典蛋白的分泌。这是关于在Dederm-LPS和单体皮层细菌的表面定殖过程中所涉及的分泌组（分泌系统及其同源效应子）的补充的最新技术，为该领域的未来研究方向铺平了道路。

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