• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Frontiers in Endocrinology >Farnesol-Like Endogenous Sesquiterpenoids in Vertebrates: The Probable but Overlooked Functional Inbrome Anti-Aging Counterpart of Juvenile Hormone of Insects?
【2h】

Farnesol-Like Endogenous Sesquiterpenoids in Vertebrates: The Probable but Overlooked Functional Inbrome Anti-Aging Counterpart of Juvenile Hormone of Insects?

机译：脊椎动物中类似法尼醇的内生倍半萜类化合物：昆虫幼体激素可能但被忽视的功能性 Inbrome抗衰老对策吗？

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Literature on the question whether the juvenile stage of vertebrates is hormonally regulated is scarce. It seems to be intuitively assumed that this stage of development is automated, and does not require any specific hormone(s). Such reasoning mimics the state of affairs in insects until it was shown that surgical removal of a tiny pair of glands in the head, the corpora allata, ended larval life and initiated metamorphosis. Decades later, the responsible hormone was found and named “juvenile hormone” (JH) because when present, it makes a larva molt into another larval stage. JH is a simple ester of farnesol, a sesquiterpenoid present in all eukaryotes. Whereas vertebrates do not have an anatomical counterpart of the corpora allata, their tissues do contain farnesol-like sesquiterpenoids (FLS). Some display typical JH activity when tested in appropriate insect bioassays. Some FLS are intermediates in the biosynthetic pathway of cholesterol, a compound that insects and nematodes (=Ecdysozoa) cannot synthesize by themselves. They ingest it as a vitamin. Until a recent (2014) reexamination of the basic principle underlying insect metamorphosis, it had been completely overlooked that the Ca2+-pump (SERCA) blocker thapsigargin is a sesquiterpenoid that mimics the absence of JH in inducing apoptosis. In our opinion, being in the juvenile state is primarily controlled by endogenous FLS that participate in controlling the activity of Ca2+-ATPases in the sarco(endo)plasmic reticulum (SERCAs), not only in insects but in all eukaryotes. Understanding the control mechanisms of being in the juvenile state may boost research not only in developmental biology in general, but also in diseases that develop after the juvenile stage, e.g., Alzheimer’s disease. It may also help to better understand some of the causes of obesity, a syndrome that holometabolous last larval insects severely suffer from, and for which they found a very drastic but efficient solution, namely metamorphosis.
机译：关于脊椎动物的幼体阶段是否受到激素调节的问题的文献很少。似乎可以凭直觉假定这一发展阶段是自动化的，不需要任何特定的激素。这种推理模仿了昆虫的状况，直到有证据表明，手术切除头部的一小对腺体（全集）结束了幼虫的生命并开始了变态。几十年后，人们发现了负责任的激素，并将其命名为“少年激素”（JH），因为当它出现时，它会使幼虫蜕变成另一个幼虫阶段。 JH是法尼醇的简单酯，法尼醇是所有真核生物中均存在的倍半萜类化合物。脊椎动物没有与全体一样的解剖结构，而它们的组织中确实含有法尼醇样的倍半萜（FLS）。当在适当的昆虫生物测定法中进行测试时，有些显示出典型的JH活性。一些FLS是胆固醇生物合成途径中的中间体，这种化合物是昆虫和线虫（= Ecdysozoa）不能自行合成的化合物。他们摄取它作为维生素。直到最近（2014年）重新审查了昆虫变态的基本原理，人们才完全忽略了Ca 2 + -pump（SERCA）阻滞剂thapsigargin是一种倍半萜类化合物，它模仿了JH在诱导中的缺失细胞凋亡。我们认为，处于幼稚状态主要受内源性FLS的控制，该FLS不仅参与昆虫，而且参与控制肌（内）质网（SERCA）中Ca 2 + -ATPases的活性。但在所有真核生物中。了解处于青少年状态的控制机制不仅可以促进一般发育生物学的研究，而且可以促进青少年阶段以后发展的疾病（例如阿尔茨海默氏病）的研究。它也可能有助于更好地了解肥胖的某些原因，这种综合征是全代谢的最后幼虫引起的严重症状，为此他们找到了一种非常有效的解决方案，即变态。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号