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首页> 美国卫生研究院文献>Frontiers in Endocrinology >Changes in Serum Sphingomyelin After Roux-en-Y Gastric Bypass Surgery Are Related to Diabetes Status
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Changes in Serum Sphingomyelin After Roux-en-Y Gastric Bypass Surgery Are Related to Diabetes Status

机译：Roux-en-Y胃绕道手术后血清鞘磷脂的变化与糖尿病状况有关

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Metabolic surgery is superior to lifestyle intervention in reducing weight and lowering glycemia and recently suggested as treatment for type 2 diabetes mellitus. Especially Roux-en-Y gastric bypass (RYGB) has been focus for much research, but still the mechanisms of action are only partly elucidated. We suggest that several mechanisms might be mediated by sphingolipids like sphingomyelin. We measured serum sphingomyelin before and up to 2 years after RYGB surgery in 220 patients, divided before surgery in one non-diabetic subgroup and two diabetic subgroups, one of which contained patients obtaining remission of type 2 diabetes after RYGB, while patients in the other still had diabetes after RYGB. Pre- and postoperative sphingomyelin levels were compared within and between groups. Sphingomyelin levels were lower in diabetic patients than in non-diabetic patients before surgery. Following RYGB, mean sphingomyelin concentration fell significantly in the non-diabetic subgroup and the preoperative difference between patients with and without diabetes disappeared. Changes in diabetic subgroups were not significant. Relative to bodyweight, an increase in sphingomyelin was seen in all subgroups, irrespective of diabetes status. We conclude that RYGB has a strong influence on sphingomyelin metabolism, as seen reflected in changed serum levels. Most significantly, no differences between the two diabetic subgroups were detected after surgery, which might suggest that patients in both groups still are in a “diabetic state” using the non-diabetic subgroup as a reference.
机译：代谢外科手术在减轻体重和降低血糖方面优于生活方式干预，最近被建议作为2型糖尿病的治疗方法。尤其是Roux-en-Y胃搭桥术（RYGB）已成为许多研究的重点，但仍仅部分阐明了作用机理。我们建议几种机制可能由鞘磷脂如鞘磷脂介导。我们测量了RYGB手术前后2年内的血清鞘磷脂，共220例患者，术前分为一个非糖尿病亚组和两个糖尿病亚组，其中一个患者包含RYGB后获得2型糖尿病缓解的患者，而另一个患者RYGB后仍患有糖尿病。比较各组内和组之间的术前和术后鞘磷脂水平。糖尿病患者的鞘磷脂水平低于手术前的非糖尿病患者。 RYGB后，非糖尿病亚组的平均鞘磷脂浓度显着下降，有无糖尿病患者的术前差异消失了。糖尿病亚组的变化不明显。相对于体重，在所有亚组中均观察到鞘磷脂增加，而与糖尿病状态无关。我们得出的结论是，RYGB对鞘磷脂的代谢有很强的影响，如血清水平的变化所反映。最重要的是，手术后未发现两个糖尿病亚组之间的差异，这可能表明这两个组的患者仍以非糖尿病亚组为参考处于“糖尿病状态”。

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