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Frontal eye field where art thou? Anatomy function and non-invasive manipulation of frontal regions involved in eye movements and associated cognitive operations

机译:额眼视野您在哪里?涉及眼球运动和相关认知操作的额叶区域的解剖功能和非侵入性操作

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摘要

The planning, control and execution of eye movements in 3D space relies on a distributed system of cortical and subcortical brain regions. Within this network, the Eye Fields have been described in animals as cortical regions in which electrical stimulation is able to trigger eye movements and influence their latency or accuracy. This review focuses on the Frontal Eye Field (FEF) a “hub” region located in Humans in the vicinity of the pre-central sulcus and the dorsal-most portion of the superior frontal sulcus. The straightforward localization of the FEF through electrical stimulation in animals is difficult to translate to the healthy human brain, particularly with non-invasive neuroimaging techniques. Hence, in the first part of this review, we describe attempts made to characterize the anatomical localization of this area in the human brain. The outcome of functional Magnetic Resonance Imaging (fMRI), Magneto-encephalography (MEG) and particularly, non-invasive mapping methods such a Transcranial Magnetic Stimulation (TMS) are described and the variability of FEF localization across individuals and mapping techniques are discussed. In the second part of this review, we will address the role of the FEF. We explore its involvement both in the physiology of fixation, saccade, pursuit, and vergence movements and in associated cognitive processes such as attentional orienting, visual awareness and perceptual modulation. Finally in the third part, we review recent evidence suggesting the high level of malleability and plasticity of these regions and associated networks to non-invasive stimulation. The exploratory, diagnostic, and therapeutic interest of such interventions for the modulation and improvement of perception in 3D space are discussed.
机译:3D空间中眼睛运动的计划,控制和执行依赖于皮质和皮质下大脑区域的分布式系统。在这个网络中,眼场在动物中被描述为皮质区域,其中电刺激能够触发眼球运动并影响其潜伏期或准确性。这篇综述的重点是额叶眼场(FEF),一个位于人中的“枢纽”区域,位于中央前沟附近和额上沟的最背面。通过电刺激在动物中对FEF的直接定位很难转化为健康的人脑,尤其是采用无创神经成像技术时。因此,在本综述的第一部分中,我们描述了试图表征该区域在人脑中的解剖学定位的尝试。描述了功能性磁共振成像(fMRI),磁脑图(MEG)的成果,尤其是无创标测方法,例如经颅磁刺激(TMS),并讨论了FEF定位在个体之间的变异性和标测技术。在本文的第二部分,我们将探讨FEF的作用。我们探索其在注视,扫视,追踪和发散运动以及相关的认知过程(如注意定向,视觉意识和知觉调节)的生理过程中的参与。最后,在第三部分中,我们回顾了最近的证据,这些证据表明这些区域以及相关网络对非侵入性刺激的高延展性和可塑性。讨论了此类干预对3D空间中感知的调制和改善的探索,诊断和治疗意义。

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