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首页> 美国卫生研究院文献>Frontiers in Cellular and Infection Microbiology >How Ocular Surface Microbiota Debuts in Type 2 Diabetes Mellitus
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How Ocular Surface Microbiota Debuts in Type 2 Diabetes Mellitus

机译：眼表微生物群如何在2型糖尿病中首演

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摘要

High glucose represents a good environment for bacterial growth on the skin, on the ocular surface (OS) and in the tears of type 2 diabetes mellitus (T2DM) patients, affecting the conjunctival bacterial community. This study aimed to investigate the OS bacterial flora of T2DM patients and healthy subjects using 16S rRNA sequencing-based bacterial identification. Among 23 healthy subjects (CON) and 31 T2DM patients, 54 eyes were examined to investigate the OS bacterial community. Factors potentially affecting the microbial growth were controlled. Results showed the OS microbiota presented higher diversity in the T2DM group than in the CON group. Bioinformatic analysis showed a lower abundance of Proteobacteria and a higher abundance of Bacteroidetes at the phyla level as well as a significantly increased abundance of Acinetobacter and Pseudomonas at the genus level in the T2DM group. The difference in OS microbiota at taxonomic level was associated with Ocular Surface Disease Index and course of T2DM. These findings indicate the OS flora in T2DM patients is significantly different from that in healthy subjects, which may be closely associated with OS discomfort and course of T2DM.
机译：高葡萄糖代表细菌在皮肤，眼表（OS）和2型糖尿病（T2DM）患者的眼泪中生长的良好环境，影响结膜细菌群落。这项研究旨在使用基于16S rRNA测序的细菌鉴定方法来调查T2DM患者和健康受试者的OS细菌菌群。在23名健康受试者（CON）和31名T2DM患者中，检查了54只眼睛以调查OS细菌群落。控制了可能影响微生物生长的因素。结果显示，T2DM组的OS菌群具有比CON组更高的多样性。生物信息学分析显示，在T2DM组中，菌群中较低的变形杆菌数量和较高的拟杆菌数量，而属中的不动杆菌和假单胞菌的含量则明显增加。分类学上的OS微生物群差异与眼表疾病指数和T2DM病程有关。这些发现表明T2DM患者的OS菌群与健康受试者显着不同，这可能与OS不适和T2DM的病程密切相关。

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