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首页> 美国卫生研究院文献>Frontiers in Human Neuroscience >Near-Infrared Spectroscopy based Neurofeedback of Prefrontal Cortex Activity: A Proof-of-Concept Study
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Near-Infrared Spectroscopy based Neurofeedback of Prefrontal Cortex Activity: A Proof-of-Concept Study

机译：基于近红外光谱的前额叶皮质活动的神经反馈：概念验证研究。

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Neurofeedback is a promising tool for treatment and rehabilitation of several patient groups. In this proof of principle study, near-infrared spectroscopy (NIRS) based neurofeedback of frontal cortical areas was investigated in healthy adults. Main aims were the assessment of learning, the effects on performance in a working memory (n-back) task and the impact of applied strategies on regulation. 13 healthy participants underwent eight sessions of NIRS based neurofeedback within 2 weeks to learn to voluntarily up-regulate hemodynamic activity in prefrontal areas. An n-back task in pre-/post measurements was used to monitor neurocognitive changes. Mean oxygenated hemoglobin (O2Hb) amplitudes over the course of the sessions as well as during the n-back task were evaluated. 12 out of 13 participants were able to regulate their frontal hemodynamic response via NIRS neurofeedback. However, no systematic learning effects were observed in frontal O2Hb amplitudes over the training course in our healthy sample. We found an impact of applied strategies in only 5 out of 13 subjects. Regarding the n-back task, neurofeedback appeared to induce more focused and specific brain activation compared to pre-training measurement. NIRS based neurofeedback is a feasible and potentially effective method, with an impact on activation patterns in a working memory task. Ceiling effects might explain the lack of a systematic learning pattern in healthy subjects. Clinical studies are needed to show effects in patients exhibiting pathological deviations in prefrontal function.
机译：神经反馈是用于治疗和康复多个患者群体的有前途的工具。在这项原理研究的证明中，对健康成年人的额叶皮层区域基于近红外光谱（NIRS）的神经反馈进行了研究。主要目标是评估学习，对工作记忆（n-back）任务中的绩效的影响以及应用策略对法规的影响。 13名健康参与者在2周内进行了8次基于NIRS的神经反馈，以学习自愿上调前额叶区域的血液动力学活动。前/后测量中的n-back任务用于监测神经认知变化。在整个疗程的过程中以及在n背任务期间评估了平均氧合血红蛋白（O2Hb）振幅。 13名参与者中有12名能够通过NIRS神经反馈调节他们的额叶血流动力学反应。但是，在我们的健康样本中，在训练过程中，额叶O2Hb振幅没有观察到系统的学习效果。我们在13个主题中只有5个发现了应用策略的影响。关于n-back任务，与训练前的测量相比，神经反馈似乎诱导了更多的专注和特定的大脑激活。基于NIRS的神经反馈是一种可行且可能有效的方法，会对工作记忆任务中的激活模式产生影响。天花板效应可能可以解释健康受试者缺乏系统的学习模式。需要进行临床研究以显示前额叶功能出现病理性偏离的患者的疗效。

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