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首页> 美国卫生研究院文献>Frontiers in Human Neuroscience >Levodopa Modulates Functional Connectivity in the Upper Beta Band Between Subthalamic Nucleus and Muscle Activity in Tonic and Phasic Motor Activity Patterns in Parkinson’s Disease
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Levodopa Modulates Functional Connectivity in the Upper Beta Band Between Subthalamic Nucleus and Muscle Activity in Tonic and Phasic Motor Activity Patterns in Parkinson’s Disease

机译：左旋多巴调节丘脑下核与肌肉活动中上丘脑下丘脑带之间的功能连通性以及帕金森氏病的强直性和相性运动活动模式

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>Introduction: Striatal dopamine depletion disrupts basal ganglia function and causes Parkinson’s disease (PD). The pathophysiology of the dopamine-dependent relationship between basal ganglia signaling and motor control, however, is not fully understood. We obtained simultaneous recordings of local field potentials (LFPs) from the subthalamic nucleus (STN) and electromyograms (EMGs) in patients with PD to investigate the impact of dopaminergic state and movement on long-range beta functional connectivity between basal ganglia and lower motor neurons.>Methods: Eight PD patients were investigated 3 months after implantation of a deep brain stimulation (DBS)-system capable of recording LFPs via chronically-implanted leads (Medtronic, ACTIVA PC+S®). We analyzed STN spectral power and its coherence with EMG in the context of two different movement paradigms (tonic wrist extension vs. alternating wrist extension and flexion) and the effect of levodopa (L-Dopa) intake using an unbiased data-driven approach to determine regions of interest (ROI).>Results: Two ROIs capturing prominent coherence within a grand average coherogram were identified. A trend of a dopamine effect was observed for the first ROI (50–150 ms after movement start) with higher STN-EMG coherence in medicated patients. Concerning the second ROI (300–500 ms after movement start), an interaction effect of L-Dopa medication and movement task was observed with higher coherence in the isometric contraction task compared to alternating movements in the medication ON state, a pattern which was reversed in L-Dopa OFF.>Discussion: L-Dopa medication may normalize functional connectivity between remote structures of the motor system with increased upper beta coherence reflecting a physiological restriction of the amount of information conveyed between remote structures. This may be necessary to maintain simple movements like isometric contraction. Our study adds dynamic properties to the complex interplay between STN spectral beta power and the nucleus’ functional connectivity to remote structures of the motor system as a function of movement and dopaminergic state. This may help to identify markers of neuronal activity relevant for more individualized programming of DBS therapy.
机译：>简介：纹状体多巴胺的消耗会破坏基底神经节功能并导致帕金森氏病（PD）。然而，尚未完全了解基底神经节信号和运动控制之间多巴胺依赖性关系的病理生理学。我们同时获得了PD患者的丘脑下丘脑核（STN）和肌电图（EMG）的局部场电位（LFP）的记录，以研究多巴胺能状态和运动对基底神经节与下运动神经元之间远程β功能连接的影响。>方法：八名PD患者在植入能够通过慢性植入导线记录LFP的深部脑刺激（DBS）系统植入3个月后进行了调查（Medtronic，ACTIVA PC + S ®< / sup>）。我们使用无偏数据驱动方法分析了两种不同的运动范式（强直腕伸展与交替腕伸展和屈曲）和左旋多巴（L-Dopa）摄入量的影响，分析了STN频谱功率及其与EMG的一致性。 >结果：确定了两个在总体平均相干图中捕获突出相干性的ROI。在药物治疗的患者中，STN-EMG一致性较高的第一个ROI（运动开始后50-150 ms）观察到多巴胺效应的趋势。关于第二个ROI（运动开始后300-500毫秒），观察到L-Dopa药物和运动任务的交互作用与等距收缩任务的相干性相比处于药物开启状态的交替运动更高，这是相反的>讨论：L-Dopa药物可以使运动系统远端结构之间的功能连接正常化，同时增加上层β一致性，反映出远端结构之间传递的信息量受到生理限制。这对于保持简单的运动（如等距收缩）可能是必要的。我们的研究为STN频谱β功率与核与运动系统和多巴胺能状态的函数与核与电机系统远程结构之间的功能连通性之间的复杂相互作用增加了动态特性。这可能有助于识别与DBS治疗更个性化编程相关的神经元活动标记。

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