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首页> 美国卫生研究院文献>Frontiers in Human Neuroscience >Anodal Transcranial Direct Current Stimulation (tDCS) Over the Right Primary Motor Cortex (M1) Impairs Implicit Motor Sequence Learning of the Ipsilateral Hand
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Anodal Transcranial Direct Current Stimulation (tDCS) Over the Right Primary Motor Cortex (M1) Impairs Implicit Motor Sequence Learning of the Ipsilateral Hand

机译：右侧初级运动皮层（M1）上的经颅经颅直流电刺激（tDCS）损害了同侧手的隐式运动序列学习

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Motor sequence learning is associated with the activation of bilateral primary motor cortices (M1). While previous data support the hypothesis that the contralateral M1 is causally involved in the acquisition as well as early consolidation of a motor sequence, the functional significance of the ipsilateral M1 has yet to be solved. Transcranial direct current stimulation (tDCS) allows the non-invasive modulation of cortical excitability. Anodal tDCS applied to the left M1 has been shown to facilitate implicit motor sequence learning of the right hand most likely due to increased excitability. The present study aims at characterizing the functional contribution of the ipsilateral (right) M1 on implicit motor sequence learning of the right hand. To this end, 24 healthy, right-handed subjects received anodal and sham tDCS to the right M1 in a counterbalanced order. Stimulation started 8 min prior to training on a variant of the serial reaction time task (SRTT) with the right hand and persists over the entire training period. The SRTT comprised a fixed eight-digit sequence. A random pattern served as control condition. Reaction times were assessed before and at the end of the acquisition (EoA) immediately after training on the SRTT. The analysis revealed significantly faster reaction times of both hands independent of tDCS condition in sequential trials. However, the gain of reaction times was significantly smaller following anodal as compared to sham tDCS. The data suggest that anodal tDCS applied to the right M1 impairs implicit motor sequence learning of both hands. The underlying mechanism likely involves alterations of the interaction between bilateral M1.
机译：运动序列学习与双侧初级运动皮层（M1）的激活有关。虽然先前的数据支持对侧M1因果关系参与运动序列的早期采集以及早期合并的假说，但同侧M1的功能意义尚待解决。经颅直流电刺激（tDCS）可以无创调节皮质兴奋性。已显示应用于左侧M1的阳极tDCS可以最有可能由于增加的兴奋性而促进右侧的隐式运动序列学习。本研究旨在表征同侧（右）M1对右手隐式运动序列学习的功能贡献。为此，有24位健康的惯用右手受试者以平衡的方式接受了右侧M1的阳极和假tDCS。在用右手训练一系列反应时间任务（SRTT）的训练之前，开始刺激8分钟，并在整个训练过程中持续进行。 SRTT包含固定的八位数字序列。随机模式作为控制条件。在接受SRTT训练后立即评估获取时间（EoA）之前和结束时的反应时间。分析显示，在连续试验中，与tDCS条件无关，两只手的反应时间明显更快。然而，与假tDCS相比，阳极后的反应时间增加明显较小。数据表明，将阳极tDCS应用于右M1会损害双手的隐式运动序列学习。潜在的机制可能涉及双边M1之间相互作用的改变。

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