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TiO2 as Photosensitizer and Photoinitiator for Synthesis of Photoactive TiO2-PEGDA Hydrogel Without Organic Photoinitiator

机译:TiO2作为光敏剂和光引发剂用于在没有有机光引发剂的情况下合成光敏性TiO2-PEGDA水凝胶

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摘要

The replacement of potentially toxic photoinitiators is of increasing interest regarding the synthesis of biomaterials by photopolymerization. Therefore, we present a new method for the preparation of UV polymerized hydrogels with TiO2 as a photoinitiator. Titania is known to be an excellent photoactive compound which is non-toxic, inert, and cheap. The so-formed hydrogels possess excellent mechanical properties, a high swelling ratio, and high thermal stability. Furthermore, no TiO2 is released from the hydrogels. Thus, the material is highly suitable for medical applications. Additionally, the present TiO2 in the hydrogels remains photoactive as demonstrated by degradation of methylene blue. This enables the application of TiO2-hydrogels in photodynamic therapy.
机译:关于通过光聚合合成生物材料,潜在毒性的光引发剂的替代越来越引起人们的兴趣。因此,我们提出了一种以TiO2为光引发剂制备紫外光聚合水凝胶的新方法。众所周知,二氧化钛是一种出色的光活性化合物,无毒,惰性且廉价。如此形成的水凝胶具有优异的机械性能,高溶胀率和高热稳定性。此外,没有从水凝胶中释放出TiO2。因此,该材料非常适合医疗应用。另外,如亚甲基蓝的降解所证明,水凝胶中存在的TiO2保持光活性。这使得TiO 2-水凝胶能够在光动力疗法中应用。

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