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首页> 美国卫生研究院文献>Frontiers in Cellular Neuroscience >Cortical Reshaping and Functional Recovery Induced by Silk Fibroin Hydrogels-Encapsulated Stem Cells Implanted in Stroke Animals
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Cortical Reshaping and Functional Recovery Induced by Silk Fibroin Hydrogels-Encapsulated Stem Cells Implanted in Stroke Animals

机译：中风动物植入丝素蛋白水凝胶封装的干细胞诱导的皮质重塑和功能恢复。

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The restitution of damaged circuitry and functional remodeling of peri-injured areas constitute two main mechanisms for sustaining recovery of the brain after stroke. In this study, a silk fibroin-based biomaterial efficiently supports the survival of intracerebrally implanted mesenchymal stem cells (mSCs) and increases functional outcomes over time in a model of cortical stroke that affects the forepaw sensory and motor representations. We show that the functional mechanisms underlying recovery are related to a substantial preservation of cortical tissue in the first days after mSCs-polymer implantation, followed by delayed cortical plasticity that involved a progressive functional disconnection between the forepaw sensory (FLs1) and caudal motor (cFLm1) representations and an emergent sensory activity in peri-lesional areas belonging to cFLm1. Our results provide evidence that mSCs integrated into silk fibroin hydrogels attenuate the cerebral damage after brain infarction inducing a delayed cortical plasticity in the peri-lesional tissue, this later a functional change described during spontaneous or training rehabilitation-induced recovery. This study shows that brain remapping and sustained recovery were experimentally favored using a stem cell-biomaterial-based approach.
机译：受损电路的恢复和周围受伤区域的功能重塑是维持中风后大脑恢复的两个主要机制。在这项研究中，基于丝素蛋白的生物材料有效地支持了脑内植入的间充质干细胞（mSCs）的存活，并随着时间的推移在皮质中风模型中增加了功能结果，从而影响了前爪的感觉和运动表现。我们显示基础恢复的功能机制与mSCs聚合物植入后的头几天皮质组织的大量保存有关，随后延迟的皮质可塑性涉及到前额感觉（FLs1）和尾部运动（cFLm1）之间的进行性功能断开）表现和属于cFLm1的病灶周围区域的新兴感觉活动。我们的结果提供证据，证明整合到丝素蛋白水凝胶中的mSCs减轻了脑梗死在病灶周围组织中延迟的皮质可塑性后的脑损伤，这是后来发生的自发性或训练性康复诱发的功能改变。这项研究表明，使用基于干细胞生物材料的方法在实验上有利于大脑重映射和持续恢复。

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