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首页> 美国卫生研究院文献>Evidence-based Complementary and Alternative Medicine : eCAM >Enhancement of Amygdaloid Neuronal Dendritic Arborization by Fresh Leaf Juice of Centella asiatica (Linn) During Growth Spurt Period in Rats
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Enhancement of Amygdaloid Neuronal Dendritic Arborization by Fresh Leaf Juice of Centella asiatica (Linn) During Growth Spurt Period in Rats

机译：积雪草在生长突增期对新鲜杏仁汁增强杏仁核神经元树突状乔化的影响

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Centella asiatica (CeA) is a creeping herb, growing in moist places in India and other Asian Countries. Ayurvedic system of medicine, an alternate system of medicine in India, uses leaves of CeA for memory enhancement. Here, we have investigated the role of CeA fresh leaf juice treatment during growth spurt period of rats on dendritic morphology of amygdaloid neurons, one of the regions concerned with learning and memory. The present study was conducted on neonatal rat pups. The rat pups (7-days-old) were fed with 2, 4 and 6 ml/kg body of fresh leaf juice of CeA for 2, 4 and 6 weeks. After the treatment period, the rats were killed, brains removed and amygdaloid neurons impregnated with Silver nitrate (Golgi staining). Amygdaloid neurons were traced using camera lucida and dendritic branching points (a measure of dendritic arborization) and intersections (a measure dendritic length) quantified. These data were compared with those of age-matched control rats. The results showed a significant increase in dendritic length (intersections) and dendritic branching points along the length of dendrites of the amygdaloid neurons of rats treated with 4 and 6 ml/kg body weight/day of CeA for longer periods of time (i.e. 4 and 6 weeks). We conclude that constituents/active principles present in CeA fresh leaf juice has neuronal dendritic growth stimulating property; hence it can be used for enhancing neuronal dendrites in stress and other neurodegenerative and memory disorders.
机译：亚洲积雪草（CeA）是一种爬行植物，生长在印度和其他亚洲国家的潮湿地方。阿育吠陀医学系统是印度的另一种医学系统，它使用CeA的叶子来增强记忆。在这里，我们已经研究了CeA新鲜叶汁处理在大鼠生长突增期对杏仁状神经元（与学习和记忆有关的区域之一）的树突形态上的作用。本研究是对新生大鼠幼崽进行的。给大鼠幼崽（7天大）喂2、4和6 ml / kg的新鲜CeA叶片汁液，持续2、4和6周。治疗期过后，将大鼠处死，取出大脑，并用硝酸银（高尔基染色）浸渍杏仁状神经元。使用相机lucida追踪杏仁核神经元，并量化树突分支点（树突乔化的量度）和交叉点（树突长度的量度）。将这些数据与年龄匹配的对照大鼠进行比较。结果显示，以4和6 ml / kg体重/天的CeA处理的大鼠在更长的时间段内（即4和6 ml / kg 6周）。我们得出的结论是，存在于CeA新鲜叶汁中的成分/活性成分具有刺激神经元树突生长的特性。因此，它可用于增强压力和其他神经变性和记忆障碍中的神经元树突。

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