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首页> 美国卫生研究院文献>Evidence-based Complementary and Alternative Medicine : eCAM >Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimers Disease Model Rats Induced by Aβ1–42
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Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimers Disease Model Rats Induced by Aβ1–42

机译：中药焕脑益聪汤提取物减少Aβ诱导的阿尔茨海默病模型大鼠脑内Tau蛋白过度磷酸化1–42

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Objective. Huannao Yicong Decoction (HYD, 还脑益聪方) has been shown to improve the learning and memory capabilities of Alzheimer's disease (AD) subjects. However, the underlying mechanism remains to be determined. Methods. Sixty Sprague-Dawley rats were divided equally and randomly into five different groups including control, positive control, and HYD granules of low dose, medium dose, and high dose by daily gavage. The sham-treated rats were also given the same volume of sterile water by gavage. Twelve SD rats were treated with the same amount of physiological saline. Twelve weeks later, learning and memory capabilities, Aβ content of the right brain and the expression of glycogen synthase kinase-3β (GSK-3β), total tau protein kinase (TTBK1), and cyclin-dependent kinase-5 (CDK-5) were tested. Results. Our results showed that high dose HYD treatment significantly improved the learning and memory capability of the AD rats and decreased the expression of TTBK1, GSK-3β, and CDK-5 in the hippocampal CA1 region. Conclusions. HYD treatment for 12 weeks significantly improved spatial learning and memory and effectively inhibited Aβ deposition, likely via reducing tau protein kinase expression and thus tau hyperphosphorylation and inflammatory injury. Taken together, these results suggest that HYD could be an effective treatment for AD.
机译：目的。焕脑益聪汤（HYD，还脑益聪方）已被证明可以改善阿尔茨海默氏病（AD）受试者的学习和记忆能力。但是，底层机制尚待确定。方法。将60只Sprague-Dawley大鼠按日常管饲法随机分为五组，分别为对照组，阳性对照组和低，中，高剂量的HYD颗粒。假治疗的大鼠也通过管饲法给予相同体积的无菌水。用相同量的生理盐水处理12只SD大鼠。十二周后，学习和记忆能力，右脑的Aβ含量以及糖原合酶激酶3β（GSK-3β），总tau蛋白激酶（TTBK1）和细胞周期蛋白依赖性激酶5（CDK-5）的表达经过测试。结果。我们的结果表明，高剂量HYD治疗可显着改善AD大鼠的学习和记忆能力，并降低海马CA1区TTBK1，GSK-3β和CDK-5的表达。结论。 HYD治疗12周可以显着改善空间学习和记忆能力，并有效抑制Aβ沉积，这可能是通过降低tau蛋白激酶的表达，从而降低tau蛋白的过度磷酸化和炎性损伤。综上，这些结果表明，HYD可能是AD的有效治疗方法。

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