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首页> 美国卫生研究院文献>Evidence-based Complementary and Alternative Medicine : eCAM >Chinese Herbal Medicine Bushen Qinggan Formula for Blood Pressure Variability and Endothelial Injury in Hypertensive Patients: A Randomized Controlled Pilot Clinical Trial
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Chinese Herbal Medicine Bushen Qinggan Formula for Blood Pressure Variability and Endothelial Injury in Hypertensive Patients: A Randomized Controlled Pilot Clinical Trial

机译：补肾清肝方对高血压患者血压变异性和内皮损伤的作用：一项随机对照临床试验

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摘要

Background. Blood pressure variability (BPV) independent of average blood pressure is related to cardiovascular damage. Meanwhile, BPV is also associated with measures of endothelial injury. Decoction, a traditional used form of Traditional Chinese Medicine (TCM), is inconvenient to prepare, carry, and store. Dispensing granules is now developing as an alternative to decoction, but the evidence supporting its clinical efficacy the same as decoction remains unclear. Objective. To examine the therapeutic effects on mean blood pressure (MBP), blood pressure variability, and endothelial function by giving Bushen Qinggan Formula, a compound Chinese Herbal Medicine and also to evaluate the difference in efficacy between decoction and granule. Methods. A total of 150 patients with hypertension were enrolled and randomly assigned to receive the placebo, Bushen Qinggan decoction, or Bushen Qinggan granule in addition to the standard medications (amlodipine-5 mg/d) for the treatment of essential hypertension (EH). The outcome was the reduction in the MBP and BPV and also included changes in the endothelial markers including endothelin-1 (ET-1) and nitric oxide (NO) after 8 weeks of treatment. Results. Compared with the control group, the Bushen Qinggan decoction and granule groups had significant improvement (P < 0.01) in BPV and endothelial founction. The level of BPV and endothelial function between decoction and granule group had no significant difference (P > 0.05). Conclusion. Based on the standard treatment, Bushen Qinggan Formula further improved BPV and endothelial function. The efficacy of Bushen Qinggan decoction and granule is similar in improving BPV and endothelial function. However, no significant antihypertensive effects could be demonstrated.
机译：背景。独立于平均血压的血压变异性（BPV）与心血管损害有关。同时，BPV还与内皮损伤的测量有关。汤剂是传统中药（TCM）的传统使用形式，不方便准备，携带和存放。分配颗粒剂现在正在替代煎剂，但尚不清楚与煎剂一样具有临床功效的证据。目的。为了研究复方中草药补肾清肝方对平均血压（MBP），血压变异性和内皮功能的治疗作用，并评估汤剂与颗粒剂之间的疗效差异。方法。总共入选了150名高血压患者，并随机分配安慰剂，补肾清肝汤或补肾清肝颗粒剂，以及用于治疗原发性高血压（EH）的标准药物（氨氯地平5μmg/ d）。结果是治疗8周后MBP和BPV降低，还包括内皮标记物的变化，包括内皮素-1（ET-1）和一氧化氮（NO）。结果。补肾清肝汤和冲剂组与对照组相比，BPV和内皮功能均有显着改善（P <0.01）。煎剂与颗粒剂组的BPV水平及内皮功能无显着性差异（P> 0.05）。结论。在标准治疗的基础上，补肾清肝方进一步改善了BPV和内皮功能。补肾清肝汤和颗粒剂在改善BPV和内皮功能方面的作用相似。但是，没有明显的降压作用。

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