• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Evidence-based Complementary and Alternative Medicine : eCAM >A Standardized Traditional Chinese Medicine Preparation Named Yejuhua Capsule Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Downregulating Toll-Like Receptor 4/Nuclear Factor-κB
【2h】

A Standardized Traditional Chinese Medicine Preparation Named Yejuhua Capsule Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Downregulating Toll-Like Receptor 4/Nuclear Factor-κB

机译：野菊花胶囊标准化中药制剂通过下调Toll样受体4 /核因子-κB减轻小鼠脂多糖诱导的急性肺损伤

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A standardized traditional Chinese medicine preparation named Yejuhua capsule (YJH) has been clinically used in treatments of various acute respiratory system diseases with high efficacy and low toxicity. In this study, we were aiming to evaluate potential effects and to elucidate underlying mechanisms of YJH against lipopolysaccharide- (LPS-) induced acute lung injury (ALI) in mice. Moreover, the chemical analysis and chromatographic fingerprint study were performed for quality evaluation and control of this drug. ALI was induced by intratracheal instillation of LPS (5 mg/kg) into the lung in mice and dexamethasone (5 mg/kg, p.o.) was used as a positive control drug. Results demonstrated that pretreatments with YJH (85, 170, and 340 mg/kg, p.o.) effectively abated LPS-induced histopathologic changes, attenuated the vascular permeability enhancement and edema, inhibited inflammatory cells migrations and protein leakages, suppressed the ability of myeloperoxidase, declined proinflammatory cytokines productions, and downregulated activations of nuclear factor-κB (NF-κB) and expressions of toll-like receptor 4 (TLR4). This study demonstrated that YJH exerted potential protective effects against LPS-induced ALI in mice and supported that YJH was a potential therapeutic drug for ALI in clinic. And its mechanisms were at least partially associated with downregulations of TLR4/NF-κB pathways.
机译：名为野菊花胶囊（YJH）的标准化中药制剂已在临床上用于治疗各种急性呼吸系统疾病，且疗效高且毒性低。在这项研究中，我们旨在评估潜在的影响，并阐明YJH抗脂多糖（LPS）诱导的小鼠急性肺损伤（ALI）的潜在机制。此外，进行了化学分析和色谱指纹图谱研究，以对该药物进行质量评估和控制。气管内向小鼠肺内注入LPS（5μg/ kg）诱导ALI，地塞米松（5μmg/ kg，p.o。）用作阳性对照药物。结果表明，YJH（85、170和340 mg / kg，口服）的预处理可有效减轻LPS诱导的组织病理学变化，减弱血管通透性增强和水肿，抑制炎症细胞迁移和蛋白渗漏，抑制髓过氧化物酶的能力，降低促炎细胞因子的产生，并下调核因子-κB（NF-κB）的激活和toll样受体4（TLR4）的表达。这项研究表明，YJH对LPS诱导的小鼠ALI具有潜在的保护作用，并支持YJH在临床上是ALI的潜在治疗药物。其机制至少部分与TLR4 /NF-κB通路的下调有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号