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首页> 美国卫生研究院文献>Evidence-based Complementary and Alternative Medicine : eCAM >The Adjuvant Activity of Epimedium Polysaccharide-Propolis Flavone Liposome on Enhancing Immune Responses to Inactivated Porcine Circovirus Vaccine in Mice
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The Adjuvant Activity of Epimedium Polysaccharide-Propolis Flavone Liposome on Enhancing Immune Responses to Inactivated Porcine Circovirus Vaccine in Mice

机译：淫羊Poly多糖蜂胶黄酮脂质体对小鼠灭活猪圆环病毒疫苗免疫反应的佐剂活性。

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Objectives. The adjuvant activity of Epimedium polysaccharide-propolis flavone liposome (EPL) was investigated in vitro and in vivo. Methods. In vitro, the effects of EPL at different concentrations on splenic lymphocytes proliferation and mRNA expression of IFN-γ and IL-6 were determined. In vivo, the adjuvant activities of EPL, EP, and mineral oil were compared in BALB/c mice through vaccination with inactivated porcine circovirus type 2 (PCV2) vaccine. Results. In vitro, EPL promoted lymphocytes proliferation and increased the mRNA expression of IFN-γ and IL-6, and the effect was significantly better than EP at all concentrations. In vivo, EPL significantly promoted the lymphocytes proliferation and the secretion of cytokines and improved the killing activity of NK cells, PCV2-specific antibody titers, and the proportion of T-cell subgroups. The effects of EPL were significantly better than EP and oil adjuvant at most time points. Conclusion. EPL could significantly improve both PCV2-specific cellular and humoral immune responses, and its medium dose had the best efficacy. Therefore, EPL would be exploited in an effective immune adjuvant for inactivated PCV2 vaccine.
机译：目标。在体外和体内研究了淫羊med多糖蜂胶黄酮脂质体（EPL）的佐剂活性。方法。在体外，确定了不同浓度的EPL对脾淋巴细胞增殖以及IFN-γ和IL-6 mRNA表达的影响。在体内，通过接种灭活的2型猪圆环病毒（PCV2）疫苗，比较了BALB / c小鼠中EPL，EP和矿物油的佐剂活性。结果。在体外，EPL促进淋巴细胞增殖并增加IFN-γ和IL-6的mRNA表达，并且在所有浓度下其效果均显着优于EP。在体内，EPL显着促进淋巴细胞增殖和细胞因子的分泌，并改善NK细胞的杀伤活性，PCV2特异性抗体滴度和T细胞亚群的比例。在大多数时间点，EPL的效果均明显优于EP和油佐剂。结论。 EPL可以显着改善PCV2特异性的细胞和体液免疫反应，其中等剂量具有最佳疗效。因此，EPL将被用作灭活PCV2疫苗的有效免疫佐剂。

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