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首页> 美国卫生研究院文献>Evidence-based Complementary and Alternative Medicine : eCAM >Investigation of the Material Basis Underlying the Correlation between Presbycusis and Kidney Deficiency in Traditional Chinese Medicine via GC/MS Metabolomics
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Investigation of the Material Basis Underlying the Correlation between Presbycusis and Kidney Deficiency in Traditional Chinese Medicine via GC/MS Metabolomics

机译：通过GC / MS代谢组学研究中枢性老花眼与肾虚相关性的物质基础

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Objective. To investigate the correlation between presbycusis and kidney deficiency as defined by traditional Chinese medicine (TCM) and its material basis from the perspective of metabolism. Methods. Pure-tone audiometry was used to test auditory function. A kidney deficiency symptom scoring table was used to measure the kidney deficiency accumulated scores of the research subjects. Gas chromatography/mass spectrometry (GC/MS) was used to measure the metabolites in the urine samples from 11 presbycusis patients and 9 elderly people with normal hearing. Results. Hearing loss in the elderly was positively correlated with kidney deficiency score in TCM. There were significant differences in urine metabolite profile between the presbycusis patients and the controls. A total of 23 differentially expressed metabolites were found. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that these metabolites were related to glutathione metabolism, amino acid metabolism, glucose metabolism, the N-methyl-D-aspartic acid (NMDA) receptor pathway, and the γ-aminobutyric acid (GABA) receptor pathway. Conclusion. Glutathione metabolism, amino acid metabolism, glucose metabolism, NMDA receptors, and GABA receptors may be related to the pathogenesis of presbycusis and may be the material basis underlying the correlation between presbycusis and kidney deficiency in TCM.
机译：目的。从新陈代谢的角度研究中医定义的老年性耳聋与肾虚的相关性及其物质基础。方法。纯音测听用于测试听觉功能。肾虚症状评分表用于测量研究对象的肾虚累积分数。气相色谱/质谱（GC / MS）用于测量11名老花眼患者和9名听力正常的老年人尿液样品中的代谢物。结果。老年人的听力下降与中医肾虚评分呈正相关。在老年患者和对照组之间，尿中代谢产物的分布存在显着差异。共发现23种差异表达的代谢产物。京都基因与基因组百科全书（KEGG）途径分析表明，这些代谢物与谷胱甘肽代谢，氨基酸代谢，葡萄糖代谢，N-甲基-D-天冬氨酸（NMDA）受体途径和γ-氨基丁酸（ GABA）受体途径。结论。谷胱甘肽代谢，氨基酸代谢，葡萄糖代谢，NMDA受体和GABA受体可能与老年性痴呆的发病机制有关，并且可能是老年性痴呆与中医肾虚相关性的物质基础。

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