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首页> 美国卫生研究院文献>Evidence-based Complementary and Alternative Medicine : eCAM >Cinnamomum zeylanicum Origanum vulgare and Curcuma longa Essential Oils: Chemical Composition Antimicrobial and Antileishmanial Activity
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Cinnamomum zeylanicum Origanum vulgare and Curcuma longa Essential Oils: Chemical Composition Antimicrobial and Antileishmanial Activity

机译：肉桂牛至和姜黄精油：化学成分抗菌和抗leishmanial活性

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The resistance mechanisms of bacteria and protozoans have evidenced the need of discover new compounds with potential pharmaceutical activity against pathogenic microorganisms. Medicinal plants have been for centuries a promising alternative as sources of new drugs. The objective of this work was to evaluate the chemical composition, antimicrobial and antileishmanial activities of Cinnamomum zeylanicum, Origanum vulgare, and Curcuma longa essential oils. Chemical analysis was performed by gas chromatography-mass spectrometry. Antimicrobial activity was performed by disk diffusion and minimum inhibitory concentration (MIC) test. Antileishmanial activity was performed against antipromastigote and intracellular amastigote of Leishmania amazonensis. Cytotoxic and nitrite production were realized in BALB/c peritoneal macrophages. The major compounds of the essential oils were cinnamic aldehyde (46.30%) in C. zeylanicum, cis-p-menth-2-en-1-ol (33.88%) and linalyl acetate (13.90%) in O. vulgare, and turmerone (55.43%) in C. longa. The MIC showed significant antimicrobial activity of C. longa essential oil against S. aureus (83.3 ± 14.43 µg/mL). Antipromastigote activity showed IC50 values >500 µg/mL to C. zeylanicum, 308.4 ± 1.402 µg/mL to O. vulgare, and 405.5 ± 1.119 µg/mL to C. longa essential oil. Activity against intracellular amastigote of L. amazonensis showed IC50 of 63.3 ± 1.369 µg/mL and cytotoxic was not observed, resulting in selectivity index higher than 15.79 to parasite. C. longa essential oil decreased nitrite production in peritoneal macrophages, but not in Leishmania-infected cells. The chemical composition of the three essential oils is directly associated to its potential biological action, as the antimicrobial activity. C. longa presented a potent antileishmanial activity against promastigote and intracellular amastigote of L. amazonensis, although this activity is not linked to nitric oxide, since C. longa essential oil inhibits its production.
机译：细菌和原生动物的耐药机制已证明需要发现对潜在病原微生物具有潜在药物活性的新化合物。几个世纪以来，药用植物一直是新药的有前途的替代品。这项工作的目的是评估肉桂，牛至和姜黄精油的化学成分，抗菌和抗衰老活性。化学分析通过气相色谱-质谱法进行。通过圆盘扩散和最小抑菌浓度（MIC）测试进行抗菌活性。抗利什曼虫活性是针对亚马逊利什曼原虫的抗前鞭毛体和胞内鞭毛体。在BALB / c腹膜巨噬细胞中实现了细胞毒性和亚硝酸盐的产生。香精油的主要化合物是玉米C中的肉桂醛（46.30％），普通麦中的顺式对薄荷脑-2-烯-1-醇（33.88％）和乙酸芳樟酯（13.90％），以及turmerone （55.43％）在龙眼。 MIC显示长梭菌精油对金黄色葡萄球菌具有显着的抗菌活性（83.3±14.43 µg / mL）。抗前鞭毛体的活性显示对玉米C的IC50值> 500 µg / mL，对普通菜的IC50值> 308.4±1.402 µg / mL，对龙眼的香精油的IC50值> 405.5±1.119 µg / mL。对 L。amazonensis 的胞内鞭毛虫活性的IC50为63.3±1.369 µ g / mL，未观察到细胞毒性，导致对寄生虫的选择性指数高于15.79。 > C. longa 精油可降低腹膜巨噬细胞中亚硝酸盐的产生，但不会降低感染Leishmania的细胞中亚硝酸盐的产生。这三种精油的化学组成与其抗微生物活性直接相关，可能与它的潜在生物学作用有关。 C. longa 对Amazon.L。amazonensis <。 / em>，尽管此活性与一氧化氮无关，但由于 longa 精油会抑制其生成。

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