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首页> 美国卫生研究院文献>Evidence-based Complementary and Alternative Medicine : eCAM >Dangguijihwang-tang and Dangguijakyak-san Prevent Menopausal Symptoms and Dangguijihwang-tang Prevents Articular Cartilage Deterioration in Ovariectomized Obese Rats with Monoiodoacetate-Induced Osteoarthritis
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Dangguijihwang-tang and Dangguijakyak-san Prevent Menopausal Symptoms and Dangguijihwang-tang Prevents Articular Cartilage Deterioration in Ovariectomized Obese Rats with Monoiodoacetate-Induced Osteoarthritis

机译：当归黄旺汤和当归黄芪散预防更年期症状当归吉黄汤预防单碘乙酸酯诱发的卵巢切除的肥胖大鼠的关节软骨恶化

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We investigated whether dangguijakyak-san (DJY) and dangguijihwang-tang (DJH), oriental medicines traditionally used for inflammatory diseases, could prevent and/or delay the progression of postmenopausal symptoms and osteoarthritis in osteoarthritis-induced estrogen-deficient rats. Treated ovariectomized (OVX) rats consumed either 1% DJY or 1% DJH in the diets. Positive-control rats were given 30 μg/kg bw 17β-estradiol and control rats were given 1% fat as were the normal-control rats. All rats received high-fat diets for 8 weeks. At the 9th week, OVX rats received articular injections of monoiodoacetate (MIA) or saline (normal control) into the right knee. At 3 weeks after MIA injection, DJY reduced visceral-fat mass and improved glucose metabolism by reducing insulin resistance, whereas DJH increased BMD and decreased insulin resistance. DJH improved weight distribution in the right knee and maximum running velocity on a treadmill at days 14 and 21 as much as those of the positive control. TNF-α, IL-1β, and IL-6 levels in articular cartilage were much higher in the control than the positive control, whereas both DJY and DJH reduced the levels to those of the positive control. The histological analysis assessed articular cartilage damage near the tidemark and proteoglycan loss in the control versus the positive control; DJY and DJH prevented this damage and proteoglycan loss. In conclusion, DJY may provide an effective treatment for improving glucose tolerance, and DJH may be appropriate for preventing osteoarthritis.
机译：我们调查了传统上用于炎症性疾病的东方药物dangguijakyak-san（DJY）和dangguijihwang-tang（DJH）是否可以预防和/或延迟骨关节炎诱发的雌激素缺乏症大鼠的绝经后症状和骨关节炎的进展。经治疗的卵巢切除（OVX）大鼠在饮食中摄入1％DJY或1％DJH。阳性对照组大鼠给予30μg/ kg bw17β-雌二醇，对照组大鼠给予1％的脂肪，与正常对照组相同。所有大鼠均接受高脂饮食，持续8周。在第9周，OVX大鼠向右膝关节注射了碘碘乙酸盐（MIA）或生理盐水（正常对照组）。注射MIA后3周，DJY通过降低胰岛素抵抗减少内脏脂肪量并改善葡萄糖代谢，而DJH则增加BMD并降低胰岛素抵抗。 DJH在第14天和第21天改善了右膝的重量分布，并在跑步机上提高了最大跑步速度，这是阳性对照的结果。对照中关节软骨中的TNF-α，IL-1β和IL-6水平比阳性对照高得多，而DJY和DJH均将其水平降低至阳性对照。组织学分析评估了相对于阳性对照，潮汐附近的关节软骨损伤和蛋白聚糖损失。 DJY和DJH防止了这种损害和蛋白聚糖的损失。总之，DJY可能为改善葡萄糖耐量提供有效的治疗方法，DJH可能适合预防骨关节炎。

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