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Integrating hepatitis B hepatitis C and HIV screening into tuberculosis entry screening for migrants in the Netherlands 2013 to 2015

机译:2013年至2015年将乙肝丙肝和艾滋病毒筛查纳入荷兰移民的结核病筛查

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摘要

We evaluated uptake and diagnostic outcomes of voluntary hepatitis B (HBV) and C virus (HCV) screening offered during routine tuberculosis entry screening to migrants in Gelderland and Amsterdam, the Netherlands, between 2013 and 2015. In Amsterdam, HIV screening was also offered. Overall, 54% (461/859) accepted screening. Prevalence of chronic HBV infection (HBsAg-positive) and HCV exposure (anti-HCV-positive) in Gelderland was 4.48% (9/201; 95% confidence interval (CI): 2.37–8.29) and 0.99% (2/203; 95% CI: 0.27–3.52), respectively, all infections were newly diagnosed. Prevalence of chronic HBV infection, HCV exposure and chronic HCV infection (HCV RNA-positive) in Amsterdam was 0.39% (1/256; 95% CI: 0.07–2.18), 1.17% (3/256; 95% CI: 0.40–3.39) and 0.39% (1/256; 95% CI: 0.07–2.18), respectively, with all chronic HBV/HCV infections previously diagnosed. No HIV infections were found. In univariate analyses, newly diagnosed chronic HBV infection was more likely in participants migrating for reasons other than work or study (4.35% vs 0.83%; odds ratio (OR) = 5.45; 95% CI: 1.12–26.60) and was less likely in participants in Amsterdam than Gelderland (0.00% vs 4.48%; OR = 0.04; 95% CI: 0.00–0.69). Regional differences in HBV prevalence might be explained by differences in the populations entering compulsory tuberculosis screening. Prescreening selection of migrants based on risk factors merits further exploration.
机译:我们评估了2013年至2015年之间在荷兰的Gelderland和阿姆斯特丹进行的常规结核病进入筛查过程中提供的自愿性乙型肝炎(HBV)和丙型肝炎病毒(HCV)筛查的摄取和诊断结果。在阿姆斯特丹,还提供了HIV筛查。总体而言,有54%(461/859)接受了筛查。 Gelderland的慢性HBV感染(HBsAg阳性)和HCV暴露(抗HCV阳性)患病率分别为4.48%(9/201; 95%置信区间(CI):2.37-8.29)和0.99%(2/203; 95%CI:±0.27–3.52),所有感染均是新诊断的。在阿姆斯特丹,慢性HBV感染,HCV暴露和慢性HCV感染(HCV RNA阳性)的患病率为0.39%(1/256; 95%CI:0.07–2.18),1.17%(3/256; 95%CI:0.40–先前诊断出的所有慢性HBV / HCV感染分别为3.39%和0.39%(1/256; 95%CI:0.07-2.18)。没有发现艾滋病毒感染。在单因素分析中,因工作或研究以外的原因而迁移的参与者中,新诊断出的慢性HBV感染可能性更高(4.35%vs 0.83%;优势比(OR)= 5.45; 95%CI:1.12-26.60),而在阿姆斯特丹的参与者比海尔德兰(0.00%vs 4.48%; OR = 0.04; 95%CI:0.00-0.69)。 HBV患病率的地区差异可以通过进入强制性结核病筛查的人群差异来解释。根据风险因素对移民进行预筛选选择值得进一步探索。

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