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Biological correlates of complex posttraumatic stress disorder—state of research and future directions

机译:复杂的创伤后应激障碍的生物学联系-研究现状和未来方向

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摘要

Complex posttraumatic stress disorder (PTSD) presents with clinical features of full or partial PTSD (re-experiencing a traumatic event, avoiding reminders of the event, and a state of hyperarousal) together with symptoms from three additional clusters (problems in emotional regulation, negative self-concept, and problems in interpersonal relations). Complex PTSD is proposed as a new diagnostic entity in ICD-11 and typically occurs after prolonged and complex trauma. Here we shortly review current knowledge regarding the biological correlates of complex PTSD and compare it to the relevant findings in PTSD. Recent studies provide support to the validity of complex PTSD as a separate diagnostic entity; however, data regarding the biological basis of the disorder are still very limited at this time. Further studies focused on complex PTSD biological correlates and replication of the initial findings are needed, including neuroimaging, neurobiochemical, genetic, and epigenetic investigations. Identification of altered biological pathways in complex PTSD may be critical to further understand the pathophysiology and optimize treatment strategies.
机译:复杂的创伤后应激障碍(PTSD)表现为全部或部分PTSD的临床特征(再次经历创伤事件,避免该事件的提醒和过度兴奋的状态)以及来自其他三个类别的症状(情绪调节问题,阴性)自我概念,以及人际关系中的问题)。复杂的PTSD被提议作为ICD-11中的一种新的诊断实体,通常发生在长期而复杂的创伤之后。在这里,我们简短地回顾了有关复杂PTSD生物学关联的当前知识,并将其与PTSD中的相关发现进行了比较。最近的研究为复杂的PTSD作为单独的诊断实体的有效性提供了支持。然而,目前关于该疾病的生物学基础的数据仍然非常有限。需要对复杂的PTSD生物学相关性和初始发现进行​​进一步研究,包括神经影像学,神经生化,遗传和表观遗传学研究。鉴定复杂PTSD中改变的生物途径可能对于进一步了解病理生理学和优化治疗策略至关重要。

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