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首页> 美国卫生研究院文献>European Journal of Psychotraumatology >Investigating biological traces of traumatic stress in changing societies: challenges and directions from the ESTSS Task Force on Neurobiology
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Investigating biological traces of traumatic stress in changing societies: challenges and directions from the ESTSS Task Force on Neurobiology

机译：调查不断变化的社会中创伤压力的生物学痕迹：ESTSS神经生物学工作组的挑战和方向

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摘要

Traumatic stress can have severe consequences for both mental and physical health. Furthermore, both psychological and biological traces of trauma increase as a function of accumulating traumatic experiences. Neurobiological research may aid in limiting the impact of traumatic stress, by leading to advances in preventive and treatment interventions. To promote the possibility for clinical implementation of novel research findings, this brief review describes timely conceptual and methodological challenges and directions in neurobiological trauma research on behalf of the Task Force “Neurobiology of Traumatic Stress” of the European Society for Traumatic Stress Studies (ESTSS). The most important conceptual challenges are the heterogeneity of disorders and existence of subtypes across diagnostic categories: differential latent profiles and trajectories regarding symptom expression and neural correlates are being unraveled; however, similar latent classes’ approaches for treatment response and neurobiological data remain scarce thus far. The key to improving the efficacy of currently available preventive interventions and treatments for trauma-related disorders lies in a better understanding and characterization of individual differences in response to trauma and interventions. This could lead to personalized treatment strategies for trauma-related disorders, based on objective information indicating whether individuals are expected to benefit from them. The most important methodological challenge identified here is the need for large consortia and meta-analyses or, rather, mega-analyses on existent data as a first step. In addition, large multicenter studies, combining novel methods for repeated sampling with more advanced statistical modeling techniques, such as machine learning, should aim to translate identified disease mechanisms into molecular blood-based biomarker combinations to predict disorder vulnerability and treatment responses.
机译：创伤性压力可能对身心健康造成严重后果。此外，创伤的心理和生物学痕迹都随着积累创伤经历而增加。神经生物学研究可能会导致预防和治疗干预措施的发展，从而有助于限制创伤性应激的影响。为促进在临床上应用新的研究结果的可能性，本简短综述代表欧洲创伤应激研究学会（ESTSS）的“创伤应激神经生物学”工作组描述了神经生物学创伤研究中的及时概念和方法学挑战和方向。 。概念上最重要的挑战是疾病的异质性和各种诊断类别中亚型的存在：关于症状表达和神经相关性的潜伏性差异和轨迹正在被揭示；但是，到目前为止，类似的潜在类别的治疗反应和神经生物学数据的方法仍然很少。提高当前有关创伤相关疾病的预防性干预措施和治疗的有效性的关键在于更好地了解和表征个体对创伤和干预措施的反应差异。根据客观信息表明个人是否有望从中受益，这可能会导致针对创伤相关疾病的个性化治疗策略。此处确定的最重要的方法挑战是第一步，需要大型财团和荟萃分析，或者对现有数据进行大规模分析。此外，大型多中心研究将重复采样的新方法与更先进的统计建模技术（例如机器学习）相结合，旨在将已识别的疾病机制转化为基于分子血液的生物标记组合，以预测疾病的易感性和治疗反应。

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