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首页> 美国卫生研究院文献>European Journal of Histochemistry : EJH >KISS1 and KISS1R expression in the human and rat carotid body and superior cervical ganglion
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KISS1 and KISS1R expression in the human and rat carotid body and superior cervical ganglion

机译：KISS1和KISS1R在人和大鼠颈动脉和上颈神经节中的表达

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摘要

KISS1 and its receptor, KISS1R, have both been found to be expressed in central nervous system, but few data are present in the literature about their distribution in peripheral nervous structures. Thus, the aim of the present study was to investigate, through immunohistochemistry, the expression and distribution of KISS1 and KISS1R in the rat and human carotid bodies and superior cervical ganglia, also with particular reference to the different cellular populations. Materials consisted of carotid bodies and superior cervical ganglia were obtained at autopsy from 10 adult subjects and sampled from 10 adult Sprague-Dawley rats. Immunohistochemistry revealed diffuse expression of KISS1 and KISS1R in type I cells of both human and rat carotid bodies, whereas type II cells were negative. In both human and rat superior cervical ganglia positive anti-KISS1 and -KISS1R immunostainings were also selectively found in ganglion cells, satellite cells being negative. Endothelial cells also showed moderate immunostaining for both KISS1 and KISS1R. The expression of both kisspeptins and kisspeptin receptors in glomic type I cells and sympathetic ganglion cells supports a modulatory role of KISS1 on peripheral chemoreception and sympathetic function. Moreover, local changes in blood flow have been considered to be involved in carotid body chemoreceptor discharge and kisspeptins and kisspeptin receptors have also been found in the endothelial cells. As a consequence, a possible role of kisspeptins in the regulation of carotid body blood flow and, indirectly, in chemoreceptor discharge may also be hypothesized.
机译：已经发现KISS1及其受体KISS1R均在中枢神经系统中表达，但文献中关于它们在周围神经结构中分布的数据很少。因此，本研究的目的是通过免疫组织化学研究KISS1和KISS1R在大鼠和人的颈动脉体和上颈神经节中的表达和分布，还特别参考了不同的细胞群体。尸体解剖时从10位成年受试者中获得了由颈动脉体和上颈神经节组成的材料，并从10只成年Sprague-Dawley大鼠中取样。免疫组织化学显示，KISS1和KISS1R在人和大鼠颈动脉I型细胞中均弥漫表达，而II型细胞则为阴性。在人和大鼠上颈神经节中，在神经节细胞中也选择性地发现了抗KISS1和-KISS1R免疫阳性，卫星细胞为阴性。内皮细胞还对KISS1和KISS1R均显示中度免疫染色。 glomic I型细胞和交感神经节细胞中Kisspeptins和Kisspeptin受体的表达均支持KISS1对周围化学感受和交感功能的调节作用。此外，已经认为局部血流变化与颈动脉体化学感受器放电有关，并且在内皮细胞中也发现了吻肽素和吻肽素受体。结果，还可以假设kisepteptin在调节颈动脉血流以及间接在化学感受器放电中的可能作用。

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