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首页> 美国卫生研究院文献>European Journal of Histochemistry : EJH >Hexavalents in spermatocytes of Robertsonian heterozygotes between Mus m. domesticus 2n 26 from the Vulcano and Lipari Islands (Aeolian Archipelago Italy)
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Hexavalents in spermatocytes of Robertsonian heterozygotes between Mus m. domesticus 2n 26 from the Vulcano and Lipari Islands (Aeolian Archipelago Italy)

机译：罗伯逊杂种小鼠之间精子细胞的六价态。乌肯诺和利帕里群岛（意大利风神群岛）的domesticus 2n 26

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The size and shape of the chromosomes, as well as the chromosomal domains that compose them, are determinants in the distribution and interaction between the bivalents within the nucleus of spermatocytes in prophase I of meiosis. Thus the nuclear architecture characteristic of the karyotype of a species can be modified by chromosomal changes such as Robertsonian (RB) chromosomes. In this study we analysed the meiotic prophase nuclear organization of the heterozygous spermatocytes from Mus musculus domesticus 2n=26, and the synaptic configuration of the hexavalent formed by the dependent Rb chromosomes Rbs 6.16, 16.10, 10.15, 15.17 and the telocentric chromosomes 6 and 17. Spreads of 88 pachytene spermatocytes from two males were studied and in all of them five metacentric bivalents, four telocentric bivalents, one hexavalent and the XY bivalent were observed. About 48% of the hexavalents formed a chain or a ring of synapsed chromosomes, the latter closed by synapsis between the short arms of telocentric chromosomes 6 and 17. About 52% of hexavalents formed an open chain of 10 synapsed chromosomal arms belonging to 6 chromosomes. In about half of the unsynapsed hexavalents one of the telocentric chromosome short arms appears associated with the X chromosome single axis, which was otherwise normally paired with the Y chromosome. The cluster of pericentromeric heterochromatin mostly determines the hexavalent’s nuclear configuration, dragging the centromeric regions and all the chromosomes towards the nuclear envelope similar to an association of five telocentric bivalents. These reiterated encounters between these chromosomes restrict the interactions with other chromosomal domains and might favour eventual rearrangements within the metacentric, telocentric or hexavalent chromosome subsets. The unsynapsed short arms of telocentric chromosomes frequently bound to the single axis of the X chromosome could further complicate the already complex segregation of hexavalent chromosomes.
机译：染色体的大小和形状，以及组成它们的染色体结构域，是减数分裂前期I精子细胞核内二价分子分布和相互作用的决定因素。因此，可以通过诸如罗伯逊（RB）染色体之类的染色体改变来修饰物种核型的核结构特征。在这项研究中，我们分析了家蝇2n = 26杂合子精母细胞的减数分裂前期核组织，以及由依赖的Rb染色体Rbs 6.16、16.10、10.15、15.17和端中心染色体6和17形成的六价突触构型。研究了来自两个雄性的88个粗线精原细胞的扩散，并观察到全部五个亚中心二价，四个端中心二价，一个六价和XY二价。大约48％的六价形成了一条突触染色体的链或环，后者通过端粒中心染色体6和17的短臂之间的突触而闭合。大约52％的六价形成了一条属于10条突触的染色体臂的开放链，属于6条染色体。 。在大约一半的未突触的六价态中，一个端胆染色体短臂似乎与X染色体单轴相关，否则通常与Y染色体配对。着丝粒周围异染色质的簇主要决定了六价核的构型，将着丝粒区域和所有染色体拖向核包膜，类似于五个端中心二价的结合。这些染色体之间的这些反复相遇限制了与其他染色体结构域的相互作用，并可能有助于在亚中心，端中心或六价染色体子集中进行最终的重排。经常与X染色体的单轴结合的端粒染色体的未突触短臂可能使六价染色体的本已复杂的分离进一步复杂化。

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