• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Eukaryotic Cell >Pho85 Kinase a Cyclin-Dependent Kinase Regulates Nuclear Accumulation of the Rim101 Transcription Factor in the Stress Response of Saccharomyces cerevisiae
【2h】

Pho85 Kinase a Cyclin-Dependent Kinase Regulates Nuclear Accumulation of the Rim101 Transcription Factor in the Stress Response of Saccharomyces cerevisiae

机译：Pho85激酶一种细胞周期蛋白依赖性激酶调节酿酒酵母在应激反应中Rim101转录因子的核积累。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The budding yeast Saccharomyces cerevisiae alters its gene expression profile in response to changing environmental conditions. The Pho85 kinase, one of the yeast cyclin-dependent kinases (CDK), is known to play an important role in the cellular response to alterations in parameters such as nutrient levels and salinity. Several genes whose expression is regulated, either directly or indirectly, by the Rim101 transcription factor become constitutively activated when Pho85 function is absent,. Because Rim101 is responsible for adaptation to alkaline conditions, this observation suggests an interaction between Pho85 and Rim101 in the response to alkaline stress. We have found that Pho85 affects neither RIM101 transcription, the proteolytic processing that is required for Rim101 activation, nor Rim101 stability. Rather, Pho85 regulates the nuclear accumulation of active Rim101, possibly via phosphorylation. Additionally, we report that Pho85 and the transcription factor Pho4 are necessary for adaptation to alkaline conditions and that PTK2 activation by Pho4 is involved in this process. These findings illustrate novel roles for the regulators of the PHO system when yeast cells cope with various environmental stresses potentially threatening their survival.
机译：萌芽的酿酒酵母会响应不断变化的环境条件而改变其基因表达谱。 Pho85激酶是酵母细胞周期蛋白依赖性激酶（CDK）之一，已知在细胞对营养物含量和盐度等参数变化的反应中起重要作用。当缺少Pho85功能时，几个表达直接或间接受Rim101转录因子调节的基因被组成性激活。由于Rim101负责适应碱性条件，因此该观察结果表明Pho85和Rim101在对碱性胁迫的响应中存在相互作用。我们发现Pho85既不影响RIM101转录，也不影响Rim101激活所需的蛋白水解过程，也不影响Rim101的稳定性。相反，Pho85可能通过磷酸化来调节活性Rim101的核积累。此外，我们报告说Pho85和转录因子Pho4是适应碱性条件所必需的，并且Pho4激活PTK2参与了此过程。这些发现说明，当酵母细胞应对各种可能威胁其生存的环境压力时，PHO系统调节剂的新作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号