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首页> 美国卫生研究院文献>ERJ Open Research >Hormonal contraception increases risk of asthma among obese but decreases it among nonobese subjects: a prospective population-based cohort study
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Hormonal contraception increases risk of asthma among obese but decreases it among nonobese subjects: a prospective population-based cohort study

机译：激素避孕增加了肥胖人群患哮喘的风险但降低了非肥胖人群患哮喘的风险：一项基于人群的前瞻性队列研究

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Epidemiological data on asthma suggest a sex difference that varies with age. Hormonal effects have been suggested as a possible explanation for these differences but there is a scarcity of evidence on these relationships. Our objective was to examine the relationship between reproductive factors and asthma risk among females and to examine whether body mass index (BMI) modifies this relationship.Female participants in the 2004 fifth decade follow-up postal survey of the Tasmanian Longitudinal Health Study formed the study population. Reproductive history and data on hormonal contraceptive (HC) use were collected on 2764 females. Multiple logistic regression was used to assess the association between the reproductive factors and current asthma.The mean age of participants was 43 years and the prevalence of middle-aged current asthma was 12.8%. Females with very early menarche (≤10 years) had higher odds of middle-aged current asthma (OR 1.91, 95% CI 1.14–3.2). Pregnancy history (number of births and age at first pregnancy) were not associated with current asthma risk at 44 years. Ever having used HCs, years of use and age started using HCs were not individually associated with current asthma risk. However, body mass index significantly modified the relationship between HC use and asthma. We found increasing years of pill use was associated with a significantly increased risk of current asthma in overweight/obese women but a reduced risk in normal weight women (interaction p=0.015).Hormonal effects from use of HCs and early menarche may contribute to the sex differential in asthma risk. Our findings suggest that in obese women with a history of long-term HC use may be at an increased risk of chronic respiratory disease, and regular monitoring for asthma and asthma symptoms may be recommended.
机译：哮喘的流行病学数据表明，性别差异随年龄而变化。激素作用已被建议作为这些差异的可能解释，但是缺乏关于这些关系的证据。我们的目标是检查女性生殖因素与哮喘风险之间的关系，并检查体重指数（BMI）是否改变了这种关系。塔斯马尼亚纵向健康研究的2004年第五十年后续邮政调查中的女性参与者组成了该研究。人口。收集了2764名女性的生殖史和激素避孕（HC）使用数据。多元logistic回归分析了生殖因素与当前哮喘的相关性。研究对象的平均年龄为43岁，当前中年哮喘的患病率为12.8％。初潮很早（≤10岁）的女性罹患中年哮喘的几率更高（OR 1.91，95％CI 1.14-3.2）。怀孕史（首次妊娠的出生人数和年龄）与目前44岁时的哮喘风险无关。曾经使用过HC，使用HC的年限和开始使用的年龄并没有分别与当前的哮喘风险相关。但是，体重指数显着改变了HC使用与哮喘之间的关系。我们发现超重/肥胖妇女服用药龄的增加与当前哮喘风险的显着增加有关，而正常体重妇女的风险降低（交互作用p = 0.015）。使用HCs和初潮初潮可能对荷尔蒙产生影响性别差异引起哮喘的风险。我们的研究结果表明，长期服用HC的肥胖女性患慢性呼吸道疾病的风险可能更高，因此建议定期监测哮喘和哮喘症状。

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