首页> 美国卫生研究院文献>Epidemiology and Infection >A study of acute respiratory disease in the community of Port Chalmers. II. Influenza A/Port Chalmers/1/73: intrafamilial spread and the effect of antibodies to the surface antigens.
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A study of acute respiratory disease in the community of Port Chalmers. II. Influenza A/Port Chalmers/1/73: intrafamilial spread and the effect of antibodies to the surface antigens.

机译:查尔默斯港社区的急性呼吸道疾病研究。二。甲型流感/ Port Chalmers / 1/73:家族内传播以及抗体对表面抗原的影响。

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摘要

During the first year of a study of respiratory disease in the semi-isolated community of Port Chalmers, New Zealand, an epidemic of clinical influenza occurred from which the variant influenza A/Port Chalmers/1/73 (H3N2) was isolated. Within a selected group of 26 families, 59 (46%) members had clinical or laboratory evidence of infection. During intrafamilial spread the infection frequency was highest for school-aged children (77%), followed by female adults (67%), infants (64%) and male adults (41%). The index infection in each family was a school-age child on 10 occasions, suggesting the role of this age group in the transmission of influenza A in this community. The secondary attack rate (SAR) of 58.3% was higher than expected. In sera taken before the 1973 epidemic, 59% of family members had detectable HI antibody and 25% NI antibody to A/England/42/72 while 38% had detectable HI antibody and 8% NI antibody to A/Port Chalmers/1/73. The relation between pre-existing antibody and infection frequency is discussed.
机译:在新西兰Port Chalmers的半隔离社区进行的呼吸道疾病研究的第一年,发生了一种临床流行性感冒,从中分离出了变异型流感A / Port Chalmers / 1/73(H3N2)。在一个选定的26个家庭中,有59个(46%)的成员具有感染的临床或实验室证据。在家庭内传播期间,学龄儿童的感染频率最高(77%),其次是女性成人(67%),婴儿(64%)和男性成人(41%)。每个家庭中的指数感染是一个10岁的学龄儿童,这表明这个年龄段在该社区传播甲型流感的作用。二次攻击率(SAR)为58.3%,高于预期。在1973年大流行之前采集的血清中,有59%的家庭成员具有可检测的HI抗体和25%的针对A / England / 42/72的NI抗体,而38%的家庭成员具有可检测的HI抗体和针对A / Port Chalmers / 1 /的8%NI抗体。 73。讨论了已有抗体与感染频率之间的关系。

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