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首页> 美国卫生研究院文献>Epidemiology and Infection >Vaccination campaign against meningococcal disease in army recruits in Italy.
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Vaccination campaign against meningococcal disease in army recruits in Italy.

机译：意大利新兵进行的针对脑膜炎球菌疾病的疫苗接种运动。

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摘要

A high attack rate (17.3/100,000) of meningococcal disease in army recruits in Italy, with 95% of the cases due to serogroup C, constituted the motivating factors to make bivalent serogroup A + C meningococcal vaccination compulsory by law for army recruits starting January 1987. Because the vaccine was given only to the new recruits entering the army, full coverage was not achieved until January 1988. Nearly 900,000 subjects (300,000 yearly) were vaccinated between January 1987 and December 1989. There were no reports of any untoward reactions to the vaccine. Of the 300,000 recruits in service each year, 52, 21, 15, 5 and 4 cases of the disease occurred in 1985, 1986, 1987, 1988 and 1989, respectively (P less than 0.001). Of the 24 cases occurring since the start of the vaccination, only two (due to serogroup C) were attributable to vaccine failure. The remaining cases were in unvaccinated recruits (15 cases) or were due to serogroups other than A or C (7 cases). The cumulative incidence of meningococcal serogroup C in the 600,000 vaccinated recruits during the period 1988-89 was 0.2/100,000 (1 case amongst 600,000 recruits), while the corresponding figure in the 600,000 unvaccinated recruits during the period 1985-6 was 11.3/100,000 (68 cases amongst 600,000 recruits) (P less than 0.001). The protective efficacy of the vaccine in 1987 was 91.2% (12 cases of meningococcal serogroup A and C disease from an average of 150,000 unvaccinated recruits observed for 1 year, and 1 case from the corresponding average of 150,000 vaccinated ones). In 1988 and in 1989 this figure could not be calculated because all recruits were vaccinated.(ABSTRACT TRUNCATED AT 250 WORDS)
机译：意大利新兵的脑膜炎球菌疾病高发病率（17.3 / 100,000），其中95％的病例是C血清群，这是促使从一月开始对新兵法律强制实施二价A + C血清群脑膜炎球菌疫苗的诱因1987年。由于仅向参军的新兵接种疫苗，因此直到1988年1月才实现全面覆盖。1987年1月至1989年12月，近900,000名受试者（每年300,000例）接种了疫苗。疫苗。在每年服务的30万名新兵中，有52、21、15、5和4例该病病例分别发生在1985、1986、1987、1988和1989年（P均小于0.001）。自接种疫苗以来发生的24例病例中，只有2例（由于C血清群）可归因于疫苗接种失败。其余病例是未接种疫苗的新兵（15例），或者是由于A或C以外的血清群引起的（7例）。在1988-89年间，600,000例疫苗接种者中，脑膜炎球菌血清群C的累积发生率是0.2 / 100,000（600,000例患者中有1例），而在1985-6期间的600,000例未接种者中，相应的数字是11.3 / 100,000（ 600,000名新兵中有68例（P小于0.001）。 1987年，该疫苗的保护效力为91.2％（从平均150,000名未接种疫苗的新兵中观察12年的A型和C型脑膜炎球菌血清群，而从相应的平均150,000名接种者中提取1例）。在1988年和1989年，由于所有新兵都进行了疫苗接种，因此无法计算出这个数字。（摘要以250字截断）

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