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首页> 美国卫生研究院文献>The EMBO Journal >A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways.
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A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways.

机译：一种新的rac靶标POSH是一种参与JNK和NF-κB信号传导途径的含SH3支架蛋白。

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摘要

The Rho, Rac and Cdc42 GTPases coordinately regulate the organization of the actin cytoskeleton and the JNK MAP kinase pathway. Mutational analysis of Rac has previously shown that these two activities are mediated by distinct cellular targets, though their identity is not known. Two Rac targets, p65(PAK) and MLK, are ser/thr kinases that have been reported to be capable of activating the JNK pathway. We present evidence that neither is the Rac target mediating JNK activation in Cos-1 cells. We have used yeast two-hybrid selection and identified a new target of Rac, POSH. This protein consists of four SH3 domains and ectopic expression leads to the activation of the JNK pathway and to nuclear translocation of NF-kappaB. When overexpressed in fibroblasts, POSH is a strong inducer of apoptosis. We propose that POSH acts as a scaffold protein and contributes to Rac-induced signal transduction pathways leading to diverse gene transcriptional changes.
机译：Rho，Rac和Cdc42 GTPases协调调节肌动蛋白细胞骨架和JNK MAP激酶途径的组织。 Rac的突变分析先前显示这两种活性是由不同的细胞靶标介导的，尽管它们的身份尚不清楚。两个Rac靶标p65（PAK）和MLK是ser / thr激酶，据报道它们能够激活JNK途径。我们提供的证据表明，Rac靶标都不是介导Cos-1细胞中JNK激活的。我们已经使用了酵母的两杂交选择，并确定了Rac的新靶标POSH。该蛋白由四个SH3结构域组成，异位表达导致JNK途径的激活和NF-κB的核易位。当在成纤维细胞中过表达时，POSH是细胞凋亡的强力诱导剂。我们建议POSH充当支架蛋白，并有助于Rac诱导的信号转导途径，导致多种基因转录变化。

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