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首页> 美国卫生研究院文献>Enzyme Research >Mode of Action of Lactoperoxidase as Related to Its Antimicrobial Activity: A Review
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Mode of Action of Lactoperoxidase as Related to Its Antimicrobial Activity: A Review

机译：乳酸过氧化物酶与其抗菌活性相关的作用方式：综述

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摘要

Lactoperoxidase is a member of the family of the mammalian heme peroxidases which have a broad spectrum of activity. Their best known effect is their antimicrobial activity that arouses much interest in in vivo and in vitro applications. In this context, the proper use of lactoperoxidase needs a good understanding of its mode of action, of the factors that favor or limit its activity, and of the features and properties of the active molecules. The first part of this review describes briefly the classification of mammalian peroxidases and their role in the human immune system and in host cell damage. The second part summarizes present knowledge on the mode of action of lactoperoxidase, with special focus on the characteristics to be taken into account for in vitro or in vivo antimicrobial use. The last part looks upon the characteristics of the active molecule produced by lactoperoxidase in the presence of thiocyanate and/or iodide with implication(s) on its antimicrobial activity.
机译：乳过氧化物酶是具有广泛活性的哺乳动物血红素过氧化物酶家族的成员。它们最著名的作用是其抗菌活性，引起了体内和体外应用的极大兴趣。在这种情况下，正确使用乳过氧化物酶需要充分了解其作用方式，有利或限制其活性的因素以及活性分子的特征和特性。本文的第一部分简要介绍了哺乳动物过氧化物酶的分类及其在人类免疫系统和宿主细胞损伤中的作用。第二部分概述了有关乳过氧化物酶作用方式的现有知识，特别侧重于在体外或体内使用抗菌剂时应考虑的特征。最后一部分着眼于在硫氰酸盐和/或碘化物存在下由乳过氧化物酶产生的活性分子的特性，这涉及其抗菌活性。

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