• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Environmental Health Perspectives >Measurement of p-nitrophenol in the urine of residents whose homes were contaminated with methyl parathion.
【2h】

Measurement of p-nitrophenol in the urine of residents whose homes were contaminated with methyl parathion.

机译：房屋被甲基对硫磷污染的居民尿液中对硝基苯酚的测定。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

During the last several years, illegal commercial application of methyl parathion (MP) in domestic settings in several U.S. Southeastern and Midwestern States has affected largely inner-city residents. As part of a multiagency response involving the U.S. Environmental Protection Agency (U.S. EPA), the Agency for Toxic Substances and Disease Registry (ATSDR), and state and local health departments, our laboratory developed a rapid, high-throughput, selective method for quantifying p-nitrophenol (PNP), a biomarker of MP exposure, using isotope dilution high-performance liquid chromatography-tandem mass spectrometry. We measured PNP in approximately 16,000 samples collected from residents of seven different states. Using this method, we were able to receive sample batches from each state; prepare, analyze, and quantify the samples for PNP; verify the results; and report the data to the health departments and ATSDR in about 48 hr. These data indicate that many residents had urinary PNP concentrations well in excess of those of the general U.S. population. In fact, their urinary PNP concentrations were more consistent with those seen in occupational settings or in poisoning cases. Although these data, when coupled with other MP metabolite data, suggest that many residents with the highest concentrations of urinary PNP had significant exposure to MP, they do not unequivocally rule out exposure to PNP resulting from environmental degradation of MP. Even with their limitations, these data were used with the assumption that all PNP was derived from MP exposure, which enabled the U.S. EPA and ATSDR to develop a comprehensive, biologically driven response that was protective of human health, especially susceptible populations, and included clinical evaluations, outreach activities, community education, integrated pest management, and decontamination of homes.
机译：在过去的几年中，美国对数个东南部和中西部州在家庭环境中非法使用甲基对硫磷（MP）的商业行为已经在很大程度上影响了市区居民。作为涉及美国环境保护局（US EPA），有毒物质和疾病登记局（ATSDR）以及州和地方卫生部门的多机构响应的一部分，我们的实验室开发了一种快速，高通量的选择性定量方法对硝基苯酚（PNP）是MP暴露的生物标志物，使用同位素稀释高效液相色谱-串联质谱法。我们测量了从七个不同州的居民那里收集的大约16,000个样本中的PNP。使用这种方法，我们可以从每个州接收样品批次。准备，分析和定量PNP样品；验证结果；并在大约48小时内将数据报告给卫生部门和ATSDR。这些数据表明，许多居民的尿中PNP浓度远远超过美国总人口。实际上，他们的尿中PNP浓度与在职业环境或中毒病例中观察到的浓度更为一致。尽管这些数据与其他MP代谢物数据结合使用，表明许多尿中PNP浓度最高的居民对MP的暴露程度很高，但他们并不能明确地排除MP环境降解所导致的PNP暴露。即使有其局限性，使用这些数据的前提是所有PNP均来自MP暴露，这使美国EPA和ATSDR能够开发出一种全面的，由生物学驱动的反应，可以保护人类健康，尤其是易感人群，并包括临床评价，外展活动，社区教育，病虫害综合治理和房屋消毒。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号