Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay.

机译：通过体外酵母生物测定确定酚类添加剂的雌激素活性。

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We used a recombinant yeast estrogen assay to assess the activity of 73 phenolic additives that are used as sunscreens, preservatives, disinfectants, antioxidants, flavorings, or for perfumery. Thirty-two of these compounds displayed activity: 22 with potencies relative to 17beta-estradiol, ranging from 1/3,000 to < 1/3,000,000, and 10 compounds with an impaired response that could not be directly compared with 17beta-estradiol. Forty-one compounds were inactive. The major criteria for activity appear to be the presence of an unhindered phenolic OH group in a para position and a molecular weight of 140-250 Da.

机译：我们使用重组酵母雌激素测定法评估了73种酚醛添加剂的活性，这些添加剂用作防晒剂，防腐剂，消毒剂，抗氧化剂，调味剂或用于香料。这些化合物中的32种显示出活性：22种具有相对于17β-雌二醇的效能，范围从1 / 3,000到<1 / 3,000,000，以及10种具有受损反应的化合物，无法与17β-雌二醇直接比较。有41种化合物没有活性。活性的主要标准似乎是在对位和分子量为140-250 Da的无阻碍的酚OH基团的存在。

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期刊名称 Environmental Health Perspectives
作者
D Miller; B B Wheals; N Beresford; J P Sumpter;
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年(卷),期 2001(109),2
年度 2001
页码 133–138
总页数 6
原文格式 PDF
正文语种
中图分类公共卫生工程;
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Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay.

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