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首页> 美国卫生研究院文献>Environmental Health Perspectives >Beta(1--3)-glucan in house dust of German homes: housing characteristics occupant behavior and relations with endotoxins allergens and molds.
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Beta(1--3)-glucan in house dust of German homes: housing characteristics occupant behavior and relations with endotoxins allergens and molds.

机译：德国房屋中的灰尘中的β（1- 3）-葡聚糖：房屋特征居住者行为以及与内毒素过敏原和霉菌的关系。

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beta(1-->3)-Glucans are potent proinflammatory agents that have been suggested to play a role in indoor-related respiratory health effects. The aim of this study was to assess whether beta(1-->3)-glucan concentrations in house dust are correlated with levels of endotoxins, allergens, and culturable mold spore counts in house dust. Further, the associations of beta(1-->3)-glucan with housing characteristics and occupant behavior were assessed. beta(1-->3)-Glucan was measured in settled house dust from living room floors of 395 homes of two German cities, Erfurt and Hamburg, with a specific enzyme immunoassay. Concentrations ranged from below the limit of detection to 19,013 microg/m(2) (22,588 microg/g dust). Concentrations per square meter were found to be correlated with endotoxins, mite and cat allergens, and culturable mold spores. Correlations were weaker when concentrations were expressed per gram of dust, indicating that variance in concentrations of all factors is largely determined by the amount of dust sampled. Associations between beta(1-->3)-glucan, housing characteristics, and occupant behavior were found for concentrations per square meter but not for concentrations per gram of dust. The following characteristics were associated with a significant increase in beta(1-->3)-glucan levels: carpets in the living room [means ratio (MR) = 1.9-2.1], keeping a dog inside (MR = 1.4), use of the home by four or more persons (MR = 1.4), use of the living room for > 180 hr/week (MR = 2.1), lower frequency of vacuum cleaning (MR = 1.6-3.0) and dust cleaning (MR = 1.2 and 1.4, respectively), and presence of mold spots during the past 12 months (MR = 1.4). We conclude that that the amount of dust sampled can be used as a proxy for hygiene and that beta(1-->3)-glucan concentrations per square meter are related to the amount of dust sampled.
机译：β（1-> 3）-葡聚糖是有效的促炎剂，已被证明在与室内有关的呼吸健康影响中起作用。这项研究的目的是评估屋尘中β（1-> 3）-葡聚糖的浓度是否与屋尘中的内毒素，过敏原和可培养的霉菌孢子数量相关。此外，评估了β（1-> 3）-葡聚糖与住房特征和乘员行为的关联。使用特定的酶免疫法测定了德国两个城市爱尔福特和汉堡395个房屋的起居室地板尘埃中的β（1-> 3）-葡聚糖。浓度范围从低于检测极限到19,013 microg / m（2）（22,588 microg / g灰尘）。发现每平方米的浓度与内毒素，螨虫和猫过敏原以及可培养的霉菌孢子有关。当浓度以每克粉尘表示时，相关性较弱，这表明所有因素的浓度差异在很大程度上取决于采样的粉尘量。发现每平方米的浓度（而不是每克粉尘的浓度）与β（1-> 3）-葡聚糖，住房特征和乘员行为之间存在关联。以下特征与β（1-> 3）-葡聚糖水平的显着增加有关：客厅的地毯[平均比（MR）= 1.9-2.1]，将狗关在里面（MR = 1.4），使用四人或以上的家庭（MR = 1.4），起居室使用时间> 180小时/周（MR = 2.1），较低的真空清洁频率（MR = 1.6-3.0）和灰尘清洁（MR = 1.2和1.4），以及在过去12个月中是否存在霉斑（MR = 1.4）。我们得出的结论是，采样的灰尘量可以用作卫生的代理，并且每平方米β（1-> 3）-葡聚糖的浓度与采样的灰尘量有关。

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