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首页> 美国卫生研究院文献>Environmental Health Perspectives >Developmental toxicity of a commercial herbicide mixture in mice: I. Effects on embryo implantation and litter size.
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Developmental toxicity of a commercial herbicide mixture in mice: I. Effects on embryo implantation and litter size.

机译：商业除草剂混合物对小鼠的发育毒性：I.对胚胎着床和产仔数的影响。

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摘要

We investigated the developmental toxicity in mice of a common commercial formulation of herbicide containing a mixture of 2,4-dichlorophenoxyacetic acid (2,4-D), mecoprop, dicamba, and inactive ingredients. Pregnant mice were exposed to one of four different doses of the herbicide mixture diluted in their drinking water, either during preimplantation and organogenesis or only during organogenesis. Litter size, birth weight, and crown-rump length were determined at birth, and pups were allowed to lactate and grow without additional herbicide exposure so that they could be subjected to additional immune, endocrine, and behavioral studies, the results of which will be reported in a separate article. At weaning, dams were sacrificed, and the number of implantation sites was determined. The data, although apparently influenced by season, showed an inverted or U-shaped dose-response pattern for reduced litter size, with the low end of the dose range producing the greatest decrease in the number of live pups born. The decrease in litter size was associated with a decrease in the number of implantation sites, but only at very low and low environmentally relevant doses. Fetotoxicity, as evidenced by a decrease in weight and crown-rump length of the newborn pups or embryo resorption, was not significantly different in the herbicide-treated litters.
机译：我们调查了除草剂的常见商业配方对小鼠的发育毒性，该除草剂包含2，4-二氯苯氧基乙酸（2,4-D），甲丙酸，麦草畏和非活性成分的混合物。怀孕小鼠在植入前和器官发生期间或仅在器官发生期间暴露于在饮用水中稀释的四种不同剂量的除草剂混合物之一。确定出生时的产仔大小，出生体重和冠臀长度，并允许幼犬泌乳和成长，而无需额外接触除草剂，以便对它们进行额外的免疫，内分泌和行为研究，其结果将是在另一篇文章中进行了报道。在断奶时，将水坝处死，并确定植入位点的数量。数据虽然显然受到季节的影响，但显示出倒立或U形的剂量反应模式，可减少产仔数，剂量范围的下限会导致出生幼仔数量的减少。凋落物大小的减少与植入位点数量的减少有关，但是仅在非常低和与环境有关的低剂量下发生。由新生幼犬的体重和冠臀长度减少或胚胎吸收减少所证明的胎儿毒性在经除草剂处理的垫料中无显着差异。

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