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首页> 美国卫生研究院文献>Environmental Health Perspectives >Polychlorinated biphenyls alter extraneuronal but not tissue dopamine concentrations in adult rat striatum: an in vivo microdialysis study.
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Polychlorinated biphenyls alter extraneuronal but not tissue dopamine concentrations in adult rat striatum: an in vivo microdialysis study.

机译：多氯联苯会改变成年大鼠纹状体中神经外神经元的浓度但不会改变组织中的多巴胺浓度：一项体内微透析研究。

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摘要

Polychlorinated biphenyls (PCBs) reduce tissue dopamine (DA) concentrations and increase media DA concentrations in both in vitro preparations of bovine adrenal chromaffin cells and adult rat striatal tissue. To determine whether these changes also occur in the intact animal, we used in vivo microdialysis to determine changes in concentrations of DA in striatal dialysates from freely moving adult male rats after exposure to 25 mg/kg/day Aroclor 1254 for varying periods of time. We also determined DA concentrations in striatal tissue obtained postmortem from similarly treated animals. The effects of PCBs on dialysate DA concentrations depended on the length of exposure; DA concentrations were significantly elevated after 3 days of exposure and were significantly reduced after exposure for periods of 1 week or longer. On the other hand, striatal tissue concentrations of DA, determined postmortem in rats exposed to PCBs for the same periods of time, were not significantly altered. We suggest that these time-dependent alterations in dialysate DA concentrations a) reflect PCB-induced alterations of both plasma membrane and vesicular DA transporter function; b) provide a more sensitive index of altered central DA function after exposure to PCBs than does measurement of postmortem tissue DA concentrations; and c) play an important role in mediating some PCB-mediated changes in behavior.
机译：在牛肾上腺嗜铬细胞的体外制剂和成年大鼠纹状体组织中，多氯联苯（PCB）均可降低组织多巴胺（DA）浓度并增加培养基DA浓度。为了确定这些变化是否也发生在完整的动物中，我们使用体内微透析法确定了在暴露于25 mg / kg / day Aroclor 1254不同时间后自由运动的成年雄性大鼠纹状体透析液中DA浓度的变化。我们还确定了从相似治疗的动物进行死后获得的纹状体组织中DA的浓度。多氯联苯对透析液DA浓度的影响取决于暴露时间的长短。暴露3天后，DA浓度显着升高，暴露1周或更长时间后，DA浓度显着降低。另一方面，在同一时间暴露于多氯联苯的大鼠中死后测定的纹状体DA浓度没有显着改变。我们认为，透析液DA浓度的这些时间依赖性变化a）反映了PCB诱导的质膜和水泡DA转运蛋白功能的变化； b）提供比死后组织DA浓度测量更敏感的中心DA功能改变指数； c）在介导多氯联苯介导的行为变化中起重要作用。

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