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首页> 美国卫生研究院文献>Environmental Health Perspectives >The Spanish toxic oil syndrome 20 years after its onset: a multidisciplinary review of scientific knowledge.
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The Spanish toxic oil syndrome 20 years after its onset: a multidisciplinary review of scientific knowledge.

机译：发病20年后的西班牙有毒油综合症：科学知识的多学科综述。

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In 1981, in Spain, the ingestion of an oil fraudulently sold as olive oil caused an outbreak of a previously unrecorded condition, later known as toxic oil syndrome (TOS), clinically characterized by intense incapacitating myalgias, marked peripheral eosinophilia, and pulmonary infiltrates. Of the 20,000 persons affected, approximately 300 died shortly after the onset of the disease and a larger number developed chronic disease. For more than 15 years, a scientific committee supported by the World Health Organization's Regional Office for Europe and by the Institute of Health Carlos III in Madrid has guided investigation intended to identify the causal agent(s), to assess toxicity and mode of action, to establish the pathogenesis of the disease, and to detect late consequences. This report summarizes advances in research on this front. No late mortality excess has been detected. Among survivors, the prevalence of some chronic conditions (e.g., sclerodermia, neurologic changes) is high. Attempts to reproduce the condition in laboratory animals have been unsuccessful, and no condition similar to TOS has been reported in the scientific literature. Laboratory findings suggest an autoimmune mechanism for TOS, such as high levels of seric soluble interleukin-2 receptor. Epidemiologic studies integrated with chemical analyses of case-related oils have shown that the disease is strongly associated with the consumption of oils containing fatty acid esters of 3-(N-phenylamino)-1,2-propanediol (PAP). These chemicals have also been found in oils synthesized under conditions simulating those hypothesized to have occurred when the toxic oil was produced in 1981. Whether PAP esters are simply markers of toxicity of oils or have the capability to induce the disease remains to be elucidated.
机译：1981年，在西班牙，摄入以橄榄油欺诈性出售的油引起了以前未记录的疾病的爆发，后来被称为有毒油综合症（TOS），临床特征是严重的无行为能力的肌痛，明显的嗜酸性粒细胞增多和肺部浸润。在2万受影响的人中，约有300人在该病发作后不久死亡，而更多的人则患有慢性疾病。 15多年来，在世界卫生组织欧洲区域办事处和马德里卡洛斯三世健康研究所的支持下，一个科学委员会为调查工作提供了指导，旨在查明原因，评估毒性和作用方式，建立疾病的发病机制，并发现晚期后果。本报告总结了这方面的研究进展。没有发现晚期死亡率过高。在幸存者中，某些慢性病（例如，硬化症，神经系统改变）的患病率很高。尝试在实验动物中重现这种状况的尝试尚未成功，并且科学文献中还没有报道过类似于TOS的状况。实验室发现提示TOS有自身免疫机制，例如高水平的血清可溶性白介素2受体。流行病学研究与病例相关油类的化学分析相结合，表明该病与食用含有3-（N-苯基氨基）-1，2-丙二醇（PAP）脂肪酸酯的油类密切相关。还可以在模拟假设在1981年生产有毒油时已经发生的油的合成条件下的油中发现这些化学物质。PAP酯仅仅是油的毒性标志物还是具有诱发疾病的能力，尚待阐明。

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