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首页> 美国卫生研究院文献>Environmental Health Perspectives >Cancer Mortality in Workers Exposed to Organochlorine Compounds in thePulp and Paper Industry: An International Collaborative Study
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Cancer Mortality in Workers Exposed to Organochlorine Compounds in thePulp and Paper Industry: An International Collaborative Study

机译：暴露于有机氯化合物中的工人的癌症死亡率制浆造纸业：国际合作研究

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The objective of this study was to evaluate cancer mortality in pulp and paper industry workers exposed to chlorinated organic compounds. We assembled a multinational cohort of workers employed between 1920 and 1996 in 11 countries. Exposure to both volatile and nonvolatile organochlorine compounds was estimated at the department level using an exposure matrix. We conducted a standardized mortality ratio (SMR) analysis based on age and calendar-period–specific national mortality rates and a Poisson regression analysis. The study population consisted of 60,468 workers. Workers exposed to volatile organochlorines experienced a deficit of all-cause [SMR = 0.91; 95% confidence interval (CI), 0.89–0.93] and all-cancer (SMR = 0.93; 95% CI, 0.89–0.97) mortality, with no evidence of increased risks for any cancer of a priori interest. There was a weak, but statistically significant, trend of increasing risk of all-cancer mortality with increasing weighted cumulative exposure. A similar deficit in all-cause (SMR = 0.94; 95% CI, 0.91–0.96) and all-cancer (SMR = 0.94; 95% CI, 0.89–1.00) mortality was observed in those exposed to non-volatile organochlorines. No excess risk was observed in cancers of a priori interest, although mortality from Hodgkin disease was elevated (SMR = 1.76; 95% CI, 1.02–2.82). In this study we found little evidence that exposure to organochlorines at the levels experienced in the pulp and paper industry is associated with an increasedrisk of cancer, apart from a weak but significant association betweenall-cancer mortality and weighted cumulative volatile organochlorineexposure.
机译：这项研究的目的是评估接触氯化有机化合物的制浆造纸工业工人的癌症死亡率。我们召集了1920年至1996年之间在11个国家/地区雇用的多国工人。使用暴露矩阵在部门级别评估了挥发性和非挥发性有机氯化合物的暴露量。我们根据年龄和日历期间特定的国家死亡率进行了标准化死亡率（SMR）分析，并进行了Poisson回归分析。研究人口包括60468名工人。接触挥发性有机氯的工人遭受全因短缺[SMR = 0.91; 95％置信区间（CI）为0.89–0.93]和全癌（SMR = 0.93; 95％CI为0.89–0.97）死亡率，没有证据表明任何先验癌症的风险增加。随着加权累积暴露的增加，全癌死亡风险增加的趋势微弱，但具有统计学意义。在暴露于非挥发性有机氯的人群中，全因死亡率（SMR = 0.94; 95％CI，0.91-0.96）和全癌（SMR = 0.94; 95％CI，0.89-1.00）相似。尽管霍奇金病的死亡率升高了（SMR = 1.76； 95％CI，1.02-2.82），但在先验研究的癌症中未观察到额外风险。在这项研究中，我们发现几乎没有证据表明在纸浆和造纸工业中经历的有机氯暴露水平与有机氯暴露量增加有关。患癌症的风险，除了全癌死亡率和加权累积挥发性有机氯接触。

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